HCSGD entry for PIK3CD

1. General information

Official gene symbolPIK3CD
Entrez ID5293
Gene full namephosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
Other gene symbolsP110DELTA PI3K p110D
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001779Natural killer cell differentiationTASbiological_process
GO:0001782B cell homeostasisIEAbiological_process
GO:0001816Cytokine productionTASbiological_process
GO:0002250Adaptive immune responseTASbiological_process
GO:0002551Mast cell chemotaxisTASbiological_process
GO:0002679Respiratory burst involved in defense responseTASbiological_process
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005829CytosolTAScellular_component
GO:0005886Plasma membraneTAScellular_component
GO:0005942Phosphatidylinositol 3-kinase complexNAScellular_component
GO:0006468Protein phosphorylationNASbiological_process
GO:0006644Phospholipid metabolic processTASbiological_process
GO:0006661Phosphatidylinositol biosynthetic processTASbiological_process
GO:0006954Inflammatory responseTASbiological_process
GO:0007165Signal transductionNASbiological_process
GO:0007173Epidermal growth factor receptor signaling pathwayTASbiological_process
GO:0008543Fibroblast growth factor receptor signaling pathwayTASbiological_process
GO:0010818T cell chemotaxisTASbiological_process
GO:0014065Phosphatidylinositol 3-kinase signalingTASbiological_process
GO:0016301Kinase activityIEAmolecular_function
GO:00163031-phosphatidylinositol-3-kinase activityNASmolecular_function
GO:0016773Phosphotransferase activity, alcohol group as acceptorIEAmolecular_function
GO:0030101Natural killer cell activationTASbiological_process
GO:0030217T cell differentiationTASbiological_process
GO:0030593Neutrophil chemotaxisTASbiological_process
GO:0035004Phosphatidylinositol 3-kinase activityTASmolecular_function
GO:00350051-phosphatidylinositol-4-phosphate 3-kinase activityIBAmolecular_function
GO:0035747Natural killer cell chemotaxisTASbiological_process
GO:0035754B cell chemotaxisTASbiological_process
GO:0036092Phosphatidylinositol-3-phosphate biosynthetic processNASbiological_process
GO:0038095Fc-epsilon receptor signaling pathwayTASbiological_process
GO:0042110T cell activationTASbiological_process
GO:0042113B cell activationTASbiological_process
GO:0042629Mast cell granuleTAScellular_component
GO:0043303Mast cell degranulationTASbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
GO:0045087Innate immune responseTASbiological_process
GO:0046854Phosphatidylinositol phosphorylationIEAbiological_process
GO:0046934Phosphatidylinositol-4,5-bisphosphate 3-kinase activityIBAmolecular_function
GO:0048011Neurotrophin TRK receptor signaling pathwayTASbiological_process
GO:0048015Phosphatidylinositol-mediated signalingIEA TASbiological_process
GO:0050852T cell receptor signaling pathwayTASbiological_process
GO:0050853B cell receptor signaling pathwayTASbiological_process
GO:0060374Mast cell differentiationTASbiological_process
GO:0072672Neutrophil extravasationTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.03297407390.90136749740.41866754811.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0952502710
GSE13712_SHEARUp0.3686838811
GSE13712_STATICUp0.4080084126
GSE19018Down-0.2391240040
GSE19899_A1Up0.4747677702
GSE19899_A2Up0.8417860827
PubMed_21979375_A1Up0.1430176315
PubMed_21979375_A2Up0.5058275781
GSE35957Down-0.1075334488
GSE36640Down-0.5810280336
GSE54402Up1.1331630715
GSE9593Up0.3826306293
GSE43922Up0.3466971420
GSE24585Up0.2370689768
GSE37065Up0.0176889792
GSE28863_A1Down-0.1705367814
GSE28863_A2Up0.0879301275
GSE28863_A3Up0.1095990880
GSE28863_A4Down-0.1222344464
GSE48662Up0.0755209235

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

XL765DB05241 -
2-((9H-PURIN-6-YLTHIO)METHYL)-5-CHLORO-3-(2-METHOXYPHENYL)QUINAZOLIN-4(3H)-ONEDB06831 -

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-30a-5pMIMAT0000087MIRT007097Luciferase reporter assay//qRT-PCR//Western blotFunctional MTI23486085
hsa-miR-10b-5pMIMAT0000254MIRT047463CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

24165795Here we report fourteen patients from seven families who were heterozygous for three different germline, gain-of-function mutations in PIK3CD (which encodes p110delta)
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