HCSGD entry for PIK3CD

1. General information

Official gene symbolPIK3CD
Entrez ID5293
Gene full namephosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
Other gene symbolsP110DELTA PI3K p110D
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001779Natural killer cell differentiationTASbiological_process
GO:0001782B cell homeostasisIEAbiological_process
GO:0001816Cytokine productionTASbiological_process
GO:0002250Adaptive immune responseTASbiological_process
GO:0002551Mast cell chemotaxisTASbiological_process
GO:0002679Respiratory burst involved in defense responseTASbiological_process
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005829CytosolTAScellular_component
GO:0005886Plasma membraneTAScellular_component
GO:0005942Phosphatidylinositol 3-kinase complexNAScellular_component
GO:0006468Protein phosphorylationNASbiological_process
GO:0006644Phospholipid metabolic processTASbiological_process
GO:0006661Phosphatidylinositol biosynthetic processTASbiological_process
GO:0006954Inflammatory responseTASbiological_process
GO:0007165Signal transductionNASbiological_process
GO:0007173Epidermal growth factor receptor signaling pathwayTASbiological_process
GO:0008543Fibroblast growth factor receptor signaling pathwayTASbiological_process
GO:0010818T cell chemotaxisTASbiological_process
GO:0014065Phosphatidylinositol 3-kinase signalingTASbiological_process
GO:0016301Kinase activityIEAmolecular_function
GO:00163031-phosphatidylinositol-3-kinase activityNASmolecular_function
GO:0016773Phosphotransferase activity, alcohol group as acceptorIEAmolecular_function
GO:0030101Natural killer cell activationTASbiological_process
GO:0030217T cell differentiationTASbiological_process
GO:0030593Neutrophil chemotaxisTASbiological_process
GO:0035004Phosphatidylinositol 3-kinase activityTASmolecular_function
GO:00350051-phosphatidylinositol-4-phosphate 3-kinase activityIBAmolecular_function
GO:0035747Natural killer cell chemotaxisTASbiological_process
GO:0035754B cell chemotaxisTASbiological_process
GO:0036092Phosphatidylinositol-3-phosphate biosynthetic processNASbiological_process
GO:0038095Fc-epsilon receptor signaling pathwayTASbiological_process
GO:0042110T cell activationTASbiological_process
GO:0042113B cell activationTASbiological_process
GO:0042629Mast cell granuleTAScellular_component
GO:0043303Mast cell degranulationTASbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
GO:0045087Innate immune responseTASbiological_process
GO:0046854Phosphatidylinositol phosphorylationIEAbiological_process
GO:0046934Phosphatidylinositol-4,5-bisphosphate 3-kinase activityIBAmolecular_function
GO:0048011Neurotrophin TRK receptor signaling pathwayTASbiological_process
GO:0048015Phosphatidylinositol-mediated signalingIEA TASbiological_process
GO:0050852T cell receptor signaling pathwayTASbiological_process
GO:0050853B cell receptor signaling pathwayTASbiological_process
GO:0060374Mast cell differentiationTASbiological_process
GO:0072672Neutrophil extravasationTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.03297407390.90136749740.41866754811.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0952502710
GSE13712_SHEARUp0.3686838811
GSE13712_STATICUp0.4080084126
GSE19018Down-0.2391240040
GSE19899_A1Up0.4747677702
GSE19899_A2Up0.8417860827
PubMed_21979375_A1Up0.1430176315
PubMed_21979375_A2Up0.5058275781
GSE35957Down-0.1075334488
GSE36640Down-0.5810280336
GSE54402Up1.1331630715
GSE9593Up0.3826306293
GSE43922Up0.3466971420
GSE24585Up0.2370689768
GSE37065Up0.0176889792
GSE28863_A1Down-0.1705367814
GSE28863_A2Up0.0879301275
GSE28863_A3Up0.1095990880
GSE28863_A4Down-0.1222344464
GSE48662Up0.0755209235

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

XL765DB05241 -
2-((9H-PURIN-6-YLTHIO)METHYL)-5-CHLORO-3-(2-METHOXYPHENYL)QUINAZOLIN-4(3H)-ONEDB06831 -

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-30a-5pMIMAT0000087MIRT007097Luciferase reporter assay//qRT-PCR//Western blotFunctional MTI23486085
hsa-miR-10b-5pMIMAT0000254MIRT047463CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

24165795Here we report fourteen patients from seven families who were heterozygous for three different germline, gain-of-function mutations in PIK3CD (which encodes p110delta)
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