HCSGD entry for PIK3CB

1. General information

Official gene symbolPIK3CB
Entrez ID5291
Gene full namephosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
Other gene symbolsP110BETA PI3K PI3KBETA PIK3C1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000187Activation of MAPK activityTASbiological_process
GO:0001952Regulation of cell-matrix adhesionIEAbiological_process
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005634NucleusIEAcellular_component
GO:0005829CytosolTAScellular_component
GO:0005886Plasma membraneIBAcellular_component
GO:0005942Phosphatidylinositol 3-kinase complexIBAcellular_component
GO:0006644Phospholipid metabolic processTASbiological_process
GO:0006661Phosphatidylinositol biosynthetic processTASbiological_process
GO:0006874Cellular calcium ion homeostasisIEAbiological_process
GO:0006914AutophagyIEAbiological_process
GO:0006935ChemotaxisTASbiological_process
GO:0007156Homophilic cell adhesionIEAbiological_process
GO:0007165Signal transductionNASbiological_process
GO:0007169Transmembrane receptor protein tyrosine kinase signaling pathwayTASbiological_process
GO:0007173Epidermal growth factor receptor signaling pathwayTASbiological_process
GO:0007186G-protein coupled receptor signaling pathwayTASbiological_process
GO:0007596Blood coagulationTASbiological_process
GO:0008286Insulin receptor signaling pathwayTASbiological_process
GO:0008543Fibroblast growth factor receptor signaling pathwayTASbiological_process
GO:0010508Positive regulation of autophagyTASbiological_process
GO:0014065Phosphatidylinositol 3-kinase signalingTASbiological_process
GO:0016301Kinase activityIEAmolecular_function
GO:00163031-phosphatidylinositol-3-kinase activityIBA IEAmolecular_function
GO:0016477Cell migrationTASbiological_process
GO:0016773Phosphotransferase activity, alcohol group as acceptorIEAmolecular_function
GO:0030168Platelet activationIEA TASbiological_process
GO:0035004Phosphatidylinositol 3-kinase activityTASmolecular_function
GO:00350051-phosphatidylinositol-4-phosphate 3-kinase activityIBAmolecular_function
GO:0038095Fc-epsilon receptor signaling pathwayTASbiological_process
GO:0038096Fc-gamma receptor signaling pathway involved in phagocytosisTASbiological_process
GO:0040016Embryonic cleavageIEAbiological_process
GO:0043560Insulin receptor substrate bindingIEAmolecular_function
GO:0044281Small molecule metabolic processTASbiological_process
GO:0045087Innate immune responseTASbiological_process
GO:0046854Phosphatidylinositol phosphorylationIEAbiological_process
GO:0046934Phosphatidylinositol-4,5-bisphosphate 3-kinase activityIBAmolecular_function
GO:0048011Neurotrophin TRK receptor signaling pathwayTASbiological_process
GO:0048015Phosphatidylinositol-mediated signalingIEA TASbiological_process
GO:0050852T cell receptor signaling pathwayTASbiological_process
GO:0050900Leukocyte migrationTASbiological_process
GO:0070527Platelet aggregationTASbiological_process
GO:2000369Regulation of clathrin-mediated endocytosisTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.00860787580.92157342050.23774176291.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0670425995
GSE13712_SHEARUp0.1006020568
GSE13712_STATICUp0.3197773371
GSE19018Up0.6747034508
GSE19899_A1Up0.7318204872
GSE19899_A2Up0.4695266226
PubMed_21979375_A1Up0.6957718317
PubMed_21979375_A2Up0.5869744608
GSE35957Down-0.0331607085
GSE36640Down-0.0486474748
GSE54402Up0.6412445799
GSE9593Up0.0779841003
GSE43922Up0.4691471260
GSE24585Up0.1424021176
GSE37065Up0.1426825942
GSE28863_A1Up0.5382406600
GSE28863_A2Up0.9957649638
GSE28863_A3Down-0.6838678189
GSE28863_A4Down-0.2437592744
GSE48662Down-0.6615217852

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

XL765DB05241 -

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-7-5pMIMAT0000252MIRT025952MicroarrayFunctional MTI (Weak)19073608
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.