HCSGD entry for PIK3CB

1. General information

Official gene symbolPIK3CB
Entrez ID5291
Gene full namephosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
Other gene symbolsP110BETA PI3K PI3KBETA PIK3C1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000187Activation of MAPK activityTASbiological_process
GO:0001952Regulation of cell-matrix adhesionIEAbiological_process
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005634NucleusIEAcellular_component
GO:0005829CytosolTAScellular_component
GO:0005886Plasma membraneIBAcellular_component
GO:0005942Phosphatidylinositol 3-kinase complexIBAcellular_component
GO:0006644Phospholipid metabolic processTASbiological_process
GO:0006661Phosphatidylinositol biosynthetic processTASbiological_process
GO:0006874Cellular calcium ion homeostasisIEAbiological_process
GO:0006914AutophagyIEAbiological_process
GO:0006935ChemotaxisTASbiological_process
GO:0007156Homophilic cell adhesionIEAbiological_process
GO:0007165Signal transductionNASbiological_process
GO:0007169Transmembrane receptor protein tyrosine kinase signaling pathwayTASbiological_process
GO:0007173Epidermal growth factor receptor signaling pathwayTASbiological_process
GO:0007186G-protein coupled receptor signaling pathwayTASbiological_process
GO:0007596Blood coagulationTASbiological_process
GO:0008286Insulin receptor signaling pathwayTASbiological_process
GO:0008543Fibroblast growth factor receptor signaling pathwayTASbiological_process
GO:0010508Positive regulation of autophagyTASbiological_process
GO:0014065Phosphatidylinositol 3-kinase signalingTASbiological_process
GO:0016301Kinase activityIEAmolecular_function
GO:00163031-phosphatidylinositol-3-kinase activityIBA IEAmolecular_function
GO:0016477Cell migrationTASbiological_process
GO:0016773Phosphotransferase activity, alcohol group as acceptorIEAmolecular_function
GO:0030168Platelet activationIEA TASbiological_process
GO:0035004Phosphatidylinositol 3-kinase activityTASmolecular_function
GO:00350051-phosphatidylinositol-4-phosphate 3-kinase activityIBAmolecular_function
GO:0038095Fc-epsilon receptor signaling pathwayTASbiological_process
GO:0038096Fc-gamma receptor signaling pathway involved in phagocytosisTASbiological_process
GO:0040016Embryonic cleavageIEAbiological_process
GO:0043560Insulin receptor substrate bindingIEAmolecular_function
GO:0044281Small molecule metabolic processTASbiological_process
GO:0045087Innate immune responseTASbiological_process
GO:0046854Phosphatidylinositol phosphorylationIEAbiological_process
GO:0046934Phosphatidylinositol-4,5-bisphosphate 3-kinase activityIBAmolecular_function
GO:0048011Neurotrophin TRK receptor signaling pathwayTASbiological_process
GO:0048015Phosphatidylinositol-mediated signalingIEA TASbiological_process
GO:0050852T cell receptor signaling pathwayTASbiological_process
GO:0050900Leukocyte migrationTASbiological_process
GO:0070527Platelet aggregationTASbiological_process
GO:2000369Regulation of clathrin-mediated endocytosisTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.00860787580.92157342050.23774176291.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0670425995
GSE13712_SHEARUp0.1006020568
GSE13712_STATICUp0.3197773371
GSE19018Up0.6747034508
GSE19899_A1Up0.7318204872
GSE19899_A2Up0.4695266226
PubMed_21979375_A1Up0.6957718317
PubMed_21979375_A2Up0.5869744608
GSE35957Down-0.0331607085
GSE36640Down-0.0486474748
GSE54402Up0.6412445799
GSE9593Up0.0779841003
GSE43922Up0.4691471260
GSE24585Up0.1424021176
GSE37065Up0.1426825942
GSE28863_A1Up0.5382406600
GSE28863_A2Up0.9957649638
GSE28863_A3Down-0.6838678189
GSE28863_A4Down-0.2437592744
GSE48662Down-0.6615217852

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

XL765DB05241 -

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-7-5pMIMAT0000252MIRT025952MicroarrayFunctional MTI (Weak)19073608
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.