HCSGD entry for PIK3C3

1. General information

Official gene symbolPIK3C3
Entrez ID5289
Gene full namephosphatidylinositol 3-kinase, catalytic subunit type 3
Other gene symbolsVPS34 hVps34
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000045Autophagic vacuole assemblyIEAbiological_process
GO:0000910CytokinesisIMPbiological_process
GO:0002224Toll-like receptor signaling pathwayTASbiological_process
GO:0004672Protein kinase activityIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005770Late endosomeIDAcellular_component
GO:0005829CytosolTAScellular_component
GO:0005930AxonemeISScellular_component
GO:0005942Phosphatidylinositol 3-kinase complexIBAcellular_component
GO:0006644Phospholipid metabolic processTASbiological_process
GO:0006661Phosphatidylinositol biosynthetic processTASbiological_process
GO:0007032Endosome organizationIEAbiological_process
GO:0008286Insulin receptor signaling pathwayTASbiological_process
GO:0016301Kinase activityIEAmolecular_function
GO:00163031-phosphatidylinositol-3-kinase activityIEA IMPmolecular_function
GO:0016485Protein processingIEAbiological_process
GO:0016773Phosphotransferase activity, alcohol group as acceptorIEAmolecular_function
GO:0030496MidbodyIDAcellular_component
GO:0034162Toll-like receptor 9 signaling pathwayTASbiological_process
GO:0036092Phosphatidylinositol-3-phosphate biosynthetic processIMP TASbiological_process
GO:0043201Response to leucineIEAbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
GO:0045022Early endosome to late endosome transportIMPbiological_process
GO:0045087Innate immune responseTASbiological_process
GO:0046854Phosphatidylinositol phosphorylationIEAbiological_process
GO:0048015Phosphatidylinositol-mediated signalingIEAbiological_process
GO:0050708Regulation of protein secretionIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.48612871090.39861536800.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.1225419455
GSE13712_SHEARDown-0.0753637193
GSE13712_STATICDown-0.1024334126
GSE19018Up0.2679923600
GSE19899_A1Down-0.0225136707
GSE19899_A2Down-0.3597395707
PubMed_21979375_A1Down-0.5720796897
PubMed_21979375_A2Down-0.1118208346
GSE35957Up0.2866783157
GSE36640Up0.3862186243
GSE54402Down-0.0600275998
GSE9593Up0.1520474298
GSE43922Down-0.2296342342
GSE24585Down-0.2415347256
GSE37065Up0.1256253963
GSE28863_A1Up0.7279690204
GSE28863_A2Up0.4162049542
GSE28863_A3Up0.0068801898
GSE28863_A4Down-0.0799253491
GSE48662Down-0.0068102203

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

N-(5-(4-CHLORO-3-(2-HYDROXY-ETHYLSULFAMOYL)- PHENYLTHIAZOLE-2-YL)-ACETAMIDEDB06836 -

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-98-5pMIMAT0000096MIRT027827MicroarrayFunctional MTI (Weak)19088304
hsa-miR-149-5pMIMAT0000450MIRT045507CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.