HCSGD entry for PIK3C3

1. General information

Official gene symbolPIK3C3
Entrez ID5289
Gene full namephosphatidylinositol 3-kinase, catalytic subunit type 3
Other gene symbolsVPS34 hVps34
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000045Autophagic vacuole assemblyIEAbiological_process
GO:0000910CytokinesisIMPbiological_process
GO:0002224Toll-like receptor signaling pathwayTASbiological_process
GO:0004672Protein kinase activityIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005770Late endosomeIDAcellular_component
GO:0005829CytosolTAScellular_component
GO:0005930AxonemeISScellular_component
GO:0005942Phosphatidylinositol 3-kinase complexIBAcellular_component
GO:0006644Phospholipid metabolic processTASbiological_process
GO:0006661Phosphatidylinositol biosynthetic processTASbiological_process
GO:0007032Endosome organizationIEAbiological_process
GO:0008286Insulin receptor signaling pathwayTASbiological_process
GO:0016301Kinase activityIEAmolecular_function
GO:00163031-phosphatidylinositol-3-kinase activityIEA IMPmolecular_function
GO:0016485Protein processingIEAbiological_process
GO:0016773Phosphotransferase activity, alcohol group as acceptorIEAmolecular_function
GO:0030496MidbodyIDAcellular_component
GO:0034162Toll-like receptor 9 signaling pathwayTASbiological_process
GO:0036092Phosphatidylinositol-3-phosphate biosynthetic processIMP TASbiological_process
GO:0043201Response to leucineIEAbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
GO:0045022Early endosome to late endosome transportIMPbiological_process
GO:0045087Innate immune responseTASbiological_process
GO:0046854Phosphatidylinositol phosphorylationIEAbiological_process
GO:0048015Phosphatidylinositol-mediated signalingIEAbiological_process
GO:0050708Regulation of protein secretionIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.48612871090.39861536800.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.1225419455
GSE13712_SHEARDown-0.0753637193
GSE13712_STATICDown-0.1024334126
GSE19018Up0.2679923600
GSE19899_A1Down-0.0225136707
GSE19899_A2Down-0.3597395707
PubMed_21979375_A1Down-0.5720796897
PubMed_21979375_A2Down-0.1118208346
GSE35957Up0.2866783157
GSE36640Up0.3862186243
GSE54402Down-0.0600275998
GSE9593Up0.1520474298
GSE43922Down-0.2296342342
GSE24585Down-0.2415347256
GSE37065Up0.1256253963
GSE28863_A1Up0.7279690204
GSE28863_A2Up0.4162049542
GSE28863_A3Up0.0068801898
GSE28863_A4Down-0.0799253491
GSE48662Down-0.0068102203

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

N-(5-(4-CHLORO-3-(2-HYDROXY-ETHYLSULFAMOYL)- PHENYLTHIAZOLE-2-YL)-ACETAMIDEDB06836 -

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-98-5pMIMAT0000096MIRT027827MicroarrayFunctional MTI (Weak)19088304
hsa-miR-149-5pMIMAT0000450MIRT045507CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.