HCSGD entry for RAPGEF6
1. General information
| Official gene symbol | RAPGEF6 |
|---|---|
| Entrez ID | 51735 |
| Gene full name | Rap guanine nucleotide exchange factor (GEF) 6 |
| Other gene symbols | KIA001LB PDZ-GEF2 PDZGEF2 RA-GEF-2 RAGEF2 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005085 | Guanyl-nucleotide exchange factor activity | IDA IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005622 | Intracellular | IEA | cellular_component |
| GO:0005737 | Cytoplasm | IEA | cellular_component |
| GO:0005886 | Plasma membrane | IDA | cellular_component |
| GO:0007264 | Small GTPase mediated signal transduction | IEA | biological_process |
| GO:0007265 | Ras protein signal transduction | NAS | biological_process |
| GO:0017016 | Ras GTPase binding | IDA | molecular_function |
| GO:0030742 | GTP-dependent protein binding | IDA | molecular_function |
| GO:0043087 | Regulation of GTPase activity | NAS | biological_process |
| GO:0051056 | Regulation of small GTPase mediated signal transduction | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0507963565 | 0.7997747692 | 0.4937217793 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.2935612869 |
| GSE13712_SHEAR | Up | 0.1369852046 |
| GSE13712_STATIC | Down | -0.0165117780 |
| GSE19018 | Down | -0.1025561166 |
| GSE19899_A1 | Up | 0.3154450396 |
| GSE19899_A2 | Up | 0.4762106165 |
| PubMed_21979375_A1 | Up | 1.0675306772 |
| PubMed_21979375_A2 | Up | 0.2907138063 |
| GSE35957 | Up | 0.0236321262 |
| GSE36640 | Down | -0.4118558749 |
| GSE54402 | Up | 0.6403498257 |
| GSE9593 | Down | -0.1489268552 |
| GSE43922 | Up | 0.4474332632 |
| GSE24585 | Up | 0.1156634174 |
| GSE37065 | Up | 0.1749320037 |
| GSE28863_A1 | Up | 0.1425685256 |
| GSE28863_A2 | Up | 0.6162784993 |
| GSE28863_A3 | Down | -0.7265948976 |
| GSE28863_A4 | Down | -0.2610564258 |
| GSE48662 | Down | -0.2413719932 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-21-5p | MIMAT0000076 | MIRT030847 | Microarray | Functional MTI (Weak) | 18591254 |
| hsa-miR-940 | MIMAT0004983 | MIRT036590 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
