HCSGD entry for TDP2
1. General information
| Official gene symbol | TDP2 |
|---|---|
| Entrez ID | 51567 |
| Gene full name | tyrosyl-DNA phosphodiesterase 2 |
| Other gene symbols | AD022 EAP2 EAPII TTRAP dJ30M3.3 hTDP2 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000287 | Magnesium ion binding | IDA TAS | molecular_function |
| GO:0003697 | Single-stranded DNA binding | IDA | molecular_function |
| GO:0003714 | Transcription corepressor activity | TAS | molecular_function |
| GO:0004518 | Nuclease activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005730 | Nucleolus | IEA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0006302 | Double-strand break repair | IDA IMP | biological_process |
| GO:0007166 | Cell surface receptor signaling pathway | TAS | biological_process |
| GO:0016605 | PML body | IDA | cellular_component |
| GO:0030145 | Manganese ion binding | IDA | molecular_function |
| GO:0036317 | Tyrosyl-RNA phosphodiesterase activity | IDA | molecular_function |
| GO:0070260 | 5'-tyrosyl-DNA phosphodiesterase activity | IDA IMP | molecular_function |
| GO:2001141 | Regulation of RNA biosynthetic process | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0297601041 | 0.9303161392 | 0.3994470678 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 1.1008780456 |
| GSE13712_SHEAR | Up | 0.3826772838 |
| GSE13712_STATIC | Up | 0.3380824814 |
| GSE19018 | Up | 0.0602464134 |
| GSE19899_A1 | Up | 0.0392022070 |
| GSE19899_A2 | Down | -0.1476162053 |
| PubMed_21979375_A1 | Up | 0.7525222699 |
| PubMed_21979375_A2 | Down | -0.0131267140 |
| GSE35957 | Up | 0.3752873406 |
| GSE36640 | Down | -0.1623658921 |
| GSE54402 | Up | 0.3530865479 |
| GSE9593 | Up | 0.6856244832 |
| GSE43922 | Down | -0.0380866439 |
| GSE24585 | Up | 0.2535755570 |
| GSE37065 | Up | 0.7621893109 |
| GSE28863_A1 | Up | 0.0002053161 |
| GSE28863_A2 | Up | 0.4032258268 |
| GSE28863_A3 | Down | -0.3655597544 |
| GSE28863_A4 | Down | -0.0864167316 |
| GSE48662 | Down | -0.1853196812 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
No target information from mirTarBase
- mirTarBase
- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
