HCSGD entry for PDE4B

1. General information

Official gene symbolPDE4B
Entrez ID5142
Gene full namephosphodiesterase 4B, cAMP-specific
Other gene symbolsDPDE4 PDE4B5 PDEIVB
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001780Neutrophil homeostasisIEA ISSbiological_process
GO:00041143',5'-cyclic-nucleotide phosphodiesterase activityISSmolecular_function
GO:00041153',5'-cyclic-AMP phosphodiesterase activityIDA IEA IGImolecular_function
GO:0005634NucleusIEAcellular_component
GO:0005829CytosolIEA TAScellular_component
GO:0005891Voltage-gated calcium channel complexISScellular_component
GO:0006198CAMP catabolic processIDA IEA IGIbiological_process
GO:0030018Z discISScellular_component
GO:0030552CAMP bindingIGImolecular_function
GO:0030593Neutrophil chemotaxisIEA ISSbiological_process
GO:0032729Positive regulation of interferon-gamma productionIMPbiological_process
GO:0032743Positive regulation of interleukin-2 productionIMPbiological_process
GO:0035690Cellular response to drugIEA ISSbiological_process
GO:0044325Ion channel bindingISSmolecular_function
GO:0046872Metal ion bindingIEAmolecular_function
GO:0048471Perinuclear region of cytoplasmIEAcellular_component
GO:0050852T cell receptor signaling pathwayIMPbiological_process
GO:0050900Leukocyte migrationISSbiological_process
GO:0071222Cellular response to lipopolysaccharideIEA ISSbiological_process
GO:0071872Cellular response to epinephrine stimulusISSbiological_process
GO:0071944Cell peripheryIEAcellular_component
GO:0086004Regulation of cardiac muscle cell contractionISSbiological_process
GO:1901841Regulation of high voltage-gated calcium channel activityISSbiological_process
GO:1901898Negative regulation of relaxation of cardiac muscleISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.00572140500.10878856430.19851176470.6307100881

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0796587691
GSE13712_SHEARUp0.0791227038
GSE13712_STATICDown-0.3515033917
GSE19018Up0.1275350979
GSE19899_A1Up0.9315010241
GSE19899_A2Up1.8180780393
PubMed_21979375_A1Up2.5538022011
PubMed_21979375_A2Up2.9356606041
GSE35957Down-0.7749907958
GSE36640Up0.3192167945
GSE54402Up0.9804947633
GSE9593Down-0.2987257163
GSE43922Up0.9998221742
GSE24585Down-0.0365178593
GSE37065Up0.8045165542
GSE28863_A1Down-0.9112840347
GSE28863_A2Down-0.0681702577
GSE28863_A3Down-1.0795566735
GSE28863_A4Down-0.1746777070
GSE48662Down-0.4184289187

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

TheophyllineDB00277 APRD00082 | DB09359
PentoxifyllineDB00806 APRD00121
EnprofyllineDB00824 APRD00273
KetotifenDB00920 APRD01061
IloprostDB01088 APRD01027
PapaverineDB01113 APRD00628 | DB07725
TheobromineDB01412 -
AmrinoneDB01427 -
(R)-MesopramDB01647 EXPT00259
RoflumilastDB01656 EXPT02802
PiclamilastDB01791 EXPT02600
RolipramDB01954 EXPT02804
3,5-Dimethyl-1-(3-Nitrophenyl)-1h-Pyrazole-4-Carboxylic Acid Ethyl EsterDB01959 EXPT00309
FilaminastDB02660 EXPT01434
8-Bromo-Adenosine-5'-MonophosphateDB03349 EXPT00332
(S)-RolipramDB03606 EXPT00229
1-(2-Chlorophenyl)-3,5-Dimethyl-1h-Pyrazole-4-Carboxylic Acid Ethyl EsterDB03807 EXPT00284
CilomilastDB03849 EXPT00920
(R)-RolipramDB04149 EXPT00228
S,S-(2-Hydroxyethyl)ThiocysteineDB04530 EXPT00954
AN2728DB05219 -
ApremilastDB05676 -
1-ethyl-N-(phenylmethyl)-4-(tetrahydro-2H-pyran-4-ylamino)-1H-pyrazolo[3,4-b]pyridine-5-carboxamideDB06909 -
4-[8-(3-nitrophenyl)-1,7-naphthyridin-6-yl]benzoic acidDB08299 -

  • MicroRNAs

    • mirTarBase
No target information from mirTarBase
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.