HCSGD entry for PDE4B

1. General information

Official gene symbolPDE4B
Entrez ID5142
Gene full namephosphodiesterase 4B, cAMP-specific
Other gene symbolsDPDE4 PDE4B5 PDEIVB
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001780Neutrophil homeostasisIEA ISSbiological_process
GO:00041143',5'-cyclic-nucleotide phosphodiesterase activityISSmolecular_function
GO:00041153',5'-cyclic-AMP phosphodiesterase activityIDA IEA IGImolecular_function
GO:0005634NucleusIEAcellular_component
GO:0005829CytosolIEA TAScellular_component
GO:0005891Voltage-gated calcium channel complexISScellular_component
GO:0006198CAMP catabolic processIDA IEA IGIbiological_process
GO:0030018Z discISScellular_component
GO:0030552CAMP bindingIGImolecular_function
GO:0030593Neutrophil chemotaxisIEA ISSbiological_process
GO:0032729Positive regulation of interferon-gamma productionIMPbiological_process
GO:0032743Positive regulation of interleukin-2 productionIMPbiological_process
GO:0035690Cellular response to drugIEA ISSbiological_process
GO:0044325Ion channel bindingISSmolecular_function
GO:0046872Metal ion bindingIEAmolecular_function
GO:0048471Perinuclear region of cytoplasmIEAcellular_component
GO:0050852T cell receptor signaling pathwayIMPbiological_process
GO:0050900Leukocyte migrationISSbiological_process
GO:0071222Cellular response to lipopolysaccharideIEA ISSbiological_process
GO:0071872Cellular response to epinephrine stimulusISSbiological_process
GO:0071944Cell peripheryIEAcellular_component
GO:0086004Regulation of cardiac muscle cell contractionISSbiological_process
GO:1901841Regulation of high voltage-gated calcium channel activityISSbiological_process
GO:1901898Negative regulation of relaxation of cardiac muscleISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.00572140500.10878856430.19851176470.6307100881

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0796587691
GSE13712_SHEARUp0.0791227038
GSE13712_STATICDown-0.3515033917
GSE19018Up0.1275350979
GSE19899_A1Up0.9315010241
GSE19899_A2Up1.8180780393
PubMed_21979375_A1Up2.5538022011
PubMed_21979375_A2Up2.9356606041
GSE35957Down-0.7749907958
GSE36640Up0.3192167945
GSE54402Up0.9804947633
GSE9593Down-0.2987257163
GSE43922Up0.9998221742
GSE24585Down-0.0365178593
GSE37065Up0.8045165542
GSE28863_A1Down-0.9112840347
GSE28863_A2Down-0.0681702577
GSE28863_A3Down-1.0795566735
GSE28863_A4Down-0.1746777070
GSE48662Down-0.4184289187

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

TheophyllineDB00277 APRD00082 | DB09359
PentoxifyllineDB00806 APRD00121
EnprofyllineDB00824 APRD00273
KetotifenDB00920 APRD01061
IloprostDB01088 APRD01027
PapaverineDB01113 APRD00628 | DB07725
TheobromineDB01412 -
AmrinoneDB01427 -
(R)-MesopramDB01647 EXPT00259
RoflumilastDB01656 EXPT02802
PiclamilastDB01791 EXPT02600
RolipramDB01954 EXPT02804
3,5-Dimethyl-1-(3-Nitrophenyl)-1h-Pyrazole-4-Carboxylic Acid Ethyl EsterDB01959 EXPT00309
FilaminastDB02660 EXPT01434
8-Bromo-Adenosine-5'-MonophosphateDB03349 EXPT00332
(S)-RolipramDB03606 EXPT00229
1-(2-Chlorophenyl)-3,5-Dimethyl-1h-Pyrazole-4-Carboxylic Acid Ethyl EsterDB03807 EXPT00284
CilomilastDB03849 EXPT00920
(R)-RolipramDB04149 EXPT00228
S,S-(2-Hydroxyethyl)ThiocysteineDB04530 EXPT00954
AN2728DB05219 -
ApremilastDB05676 -
1-ethyl-N-(phenylmethyl)-4-(tetrahydro-2H-pyran-4-ylamino)-1H-pyrazolo[3,4-b]pyridine-5-carboxamideDB06909 -
4-[8-(3-nitrophenyl)-1,7-naphthyridin-6-yl]benzoic acidDB08299 -

  • MicroRNAs

  • mirTarBase
No target information from mirTarBase
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.