HCSGD entry for TLR8

1. General information

Official gene symbolTLR8
Entrez ID51311
Gene full nametoll-like receptor 8
Other gene symbolsCD288
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000139Golgi membraneTAScellular_component
GO:0002224Toll-like receptor signaling pathwayTASbiological_process
GO:0002282Microglial cell activation involved in immune responseIEAbiological_process
GO:0002755MyD88-dependent toll-like receptor signaling pathwayIEAbiological_process
GO:0003677DNA bindingIDAmolecular_function
GO:0003723RNA bindingTASmolecular_function
GO:0003725Double-stranded RNA bindingIDAmolecular_function
GO:0003727Single-stranded RNA bindingIDAmolecular_function
GO:0004872Receptor activityNASmolecular_function
GO:0005789Endoplasmic reticulum membraneTAScellular_component
GO:0006954Inflammatory responseIEAbiological_process
GO:0007249I-kappaB kinase/NF-kappaB signalingIDAbiological_process
GO:0008144Drug bindingIEAmolecular_function
GO:0009615Response to virusIDAbiological_process
GO:0010008Endosome membraneTAScellular_component
GO:0016021Integral component of membraneICcellular_component
GO:0016064Immunoglobulin mediated immune responseTASbiological_process
GO:0034158Toll-like receptor 8 signaling pathwayIEAbiological_process
GO:0034162Toll-like receptor 9 signaling pathwayTASbiological_process
GO:0036020Endolysosome membraneTAScellular_component
GO:0045078Positive regulation of interferon-gamma biosynthetic processIDAbiological_process
GO:0045087Innate immune responseNAS TASbiological_process
GO:0045089Positive regulation of innate immune responseIDAbiological_process
GO:0045356Positive regulation of interferon-alpha biosynthetic processIDAbiological_process
GO:0045359Positive regulation of interferon-beta biosynthetic processIDAbiological_process
GO:0045416Positive regulation of interleukin-8 biosynthetic processIMPbiological_process
GO:0050707Regulation of cytokine secretionIEAbiological_process
GO:0051607Defense response to virusIMPbiological_process
GO:0052033Pathogen-associated molecular pattern dependent induction by symbiont of host innate immune responseIEAbiological_process
GO:0071260Cellular response to mechanical stimulusIEPbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.69454272250.85929726830.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0297806590
GSE13712_SHEARUp0.0947870977
GSE13712_STATICDown-0.0587796100
GSE19018Up0.2695261837
GSE19899_A1Up0.1824466797
GSE19899_A2Down-0.0240911420
PubMed_21979375_A1Up0.0449854800
PubMed_21979375_A2Down-0.0332202269
GSE35957Up0.2040016402
GSE36640Down-0.0189891224
GSE54402Up0.0081840257
GSE9593Up0.0497436255
GSE43922Up0.0198779802
GSE24585Up0.2261838284
GSE37065Down-0.0980177178
GSE28863_A1Down-0.0461236701
GSE28863_A2Up0.1261066233
GSE28863_A3Down-0.0513544659
GSE28863_A4Down-0.0668618007
GSE48662Down-0.1106704089

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

ImiquimodDB00724 APRD01030

  • MicroRNAs

    • mirTarBase
No target information from mirTarBase
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 4 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

25949919We have identified the induction of T cell senescence as a novel mechanism utilized by human tumor cells to induce immune suppression, and provided a new strategy using TLR8 ligands to reverse tumor immunosuppressive effects for tumor immunotherapy
25231413TLR8 signaling enhances tumor immunity by preventing tumor-induced T-cell senescence
25231413Importantly, activation of TLR8 signaling in tumor cells can block the induction and reverse the suppression of senescent naive and tumor-specific T cells in vitro and in vivo, resulting in enhanced anti-tumor immunity
23506673We reviewed evidences suggesting that miRNAs can modulate TLR signaling mainly by three different mechanisms: 1) miRNAs can directly target components of the TLR signaling system, 2) miRNA expression can be directly regulated by TLRs pathway activation and 3) miRNAs can directly activate the RNA-sensing TLRs, like TLR-8, in humans
23355732In addition, we demonstrated that manipulation of TLR8 signaling in gammadelta Treg cells can block gammadelta Treg-induced conversion of T cells and DCs into senescent cells in vitro and in vivo
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