HCSGD entry for TLR8

1. General information

Official gene symbolTLR8
Entrez ID51311
Gene full nametoll-like receptor 8
Other gene symbolsCD288
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000139Golgi membraneTAScellular_component
GO:0002224Toll-like receptor signaling pathwayTASbiological_process
GO:0002282Microglial cell activation involved in immune responseIEAbiological_process
GO:0002755MyD88-dependent toll-like receptor signaling pathwayIEAbiological_process
GO:0003677DNA bindingIDAmolecular_function
GO:0003723RNA bindingTASmolecular_function
GO:0003725Double-stranded RNA bindingIDAmolecular_function
GO:0003727Single-stranded RNA bindingIDAmolecular_function
GO:0004872Receptor activityNASmolecular_function
GO:0005789Endoplasmic reticulum membraneTAScellular_component
GO:0006954Inflammatory responseIEAbiological_process
GO:0007249I-kappaB kinase/NF-kappaB signalingIDAbiological_process
GO:0008144Drug bindingIEAmolecular_function
GO:0009615Response to virusIDAbiological_process
GO:0010008Endosome membraneTAScellular_component
GO:0016021Integral component of membraneICcellular_component
GO:0016064Immunoglobulin mediated immune responseTASbiological_process
GO:0034158Toll-like receptor 8 signaling pathwayIEAbiological_process
GO:0034162Toll-like receptor 9 signaling pathwayTASbiological_process
GO:0036020Endolysosome membraneTAScellular_component
GO:0045078Positive regulation of interferon-gamma biosynthetic processIDAbiological_process
GO:0045087Innate immune responseNAS TASbiological_process
GO:0045089Positive regulation of innate immune responseIDAbiological_process
GO:0045356Positive regulation of interferon-alpha biosynthetic processIDAbiological_process
GO:0045359Positive regulation of interferon-beta biosynthetic processIDAbiological_process
GO:0045416Positive regulation of interleukin-8 biosynthetic processIMPbiological_process
GO:0050707Regulation of cytokine secretionIEAbiological_process
GO:0051607Defense response to virusIMPbiological_process
GO:0052033Pathogen-associated molecular pattern dependent induction by symbiont of host innate immune responseIEAbiological_process
GO:0071260Cellular response to mechanical stimulusIEPbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.69454272250.85929726830.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0297806590
GSE13712_SHEARUp0.0947870977
GSE13712_STATICDown-0.0587796100
GSE19018Up0.2695261837
GSE19899_A1Up0.1824466797
GSE19899_A2Down-0.0240911420
PubMed_21979375_A1Up0.0449854800
PubMed_21979375_A2Down-0.0332202269
GSE35957Up0.2040016402
GSE36640Down-0.0189891224
GSE54402Up0.0081840257
GSE9593Up0.0497436255
GSE43922Up0.0198779802
GSE24585Up0.2261838284
GSE37065Down-0.0980177178
GSE28863_A1Down-0.0461236701
GSE28863_A2Up0.1261066233
GSE28863_A3Down-0.0513544659
GSE28863_A4Down-0.0668618007
GSE48662Down-0.1106704089

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

ImiquimodDB00724 APRD01030

  • MicroRNAs

  • mirTarBase
No target information from mirTarBase
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 4 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

25949919We have identified the induction of T cell senescence as a novel mechanism utilized by human tumor cells to induce immune suppression, and provided a new strategy using TLR8 ligands to reverse tumor immunosuppressive effects for tumor immunotherapy
25231413TLR8 signaling enhances tumor immunity by preventing tumor-induced T-cell senescence
25231413Importantly, activation of TLR8 signaling in tumor cells can block the induction and reverse the suppression of senescent naive and tumor-specific T cells in vitro and in vivo, resulting in enhanced anti-tumor immunity
23506673We reviewed evidences suggesting that miRNAs can modulate TLR signaling mainly by three different mechanisms: 1) miRNAs can directly target components of the TLR signaling system, 2) miRNA expression can be directly regulated by TLRs pathway activation and 3) miRNAs can directly activate the RNA-sensing TLRs, like TLR-8, in humans
23355732In addition, we demonstrated that manipulation of TLR8 signaling in gammadelta Treg cells can block gammadelta Treg-induced conversion of T cells and DCs into senescent cells in vitro and in vivo
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