HCSGD entry for PCSK5

1. General information

Official gene symbolPCSK5
Entrez ID5125
Gene full nameproprotein convertase subtilisin/kexin type 5
Other gene symbolsPC5 PC6 PC6A SPC6
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001822Kidney developmentIMP ISSbiological_process
GO:0002001Renin secretion into blood streamIEPbiological_process
GO:0004252Serine-type endopeptidase activityIDA IEAmolecular_function
GO:0005615Extracellular spaceIBA ISScellular_component
GO:0005794Golgi apparatusISScellular_component
GO:0005796Golgi lumenTAScellular_component
GO:0006465Signal peptide processingIDAbiological_process
GO:0006508ProteolysisIEAbiological_process
GO:0007267Cell-cell signalingTASbiological_process
GO:0007507Heart developmentISSbiological_process
GO:0007566Embryo implantationISSbiological_process
GO:0009952Anterior/posterior pattern specificationIMPbiological_process
GO:0012505Endomembrane systemIEAcellular_component
GO:0016021Integral component of membraneIEAcellular_component
GO:0016485Protein processingIDAbiological_process
GO:0016486Peptide hormone processingIDAbiological_process
GO:0019058Viral life cycleIEP ISSbiological_process
GO:0030141Secretory granuleISScellular_component
GO:0030323Respiratory tube developmentISSbiological_process
GO:0032455Nerve growth factor processingTASbiological_process
GO:0035108Limb morphogenesisISSbiological_process
GO:0042089Cytokine biosynthetic processISSbiological_process
GO:0042277Peptide bindingISSmolecular_function
GO:0043043Peptide biosynthetic processIDAbiological_process
GO:0048011Neurotrophin TRK receptor signaling pathwayTASbiological_process
GO:0048566Embryonic digestive tract developmentIMP ISSbiological_process
GO:0048706Embryonic skeletal system developmentIMP ISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.65869880700.00461011360.99999024730.1374210646

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.3634254909
GSE13712_SHEARDown-1.8339060008
GSE13712_STATICDown-1.2662388431
GSE19018Down-0.8070860456
GSE19899_A1Down-0.1150375305
GSE19899_A2Down-0.5422256814
PubMed_21979375_A1Down-0.7554489956
PubMed_21979375_A2Down-0.5121054157
GSE35957Down-0.2837489982
GSE36640Up1.2771588644
GSE54402Down-2.0460781006
GSE9593Up0.1688379787
GSE43922Down-0.2990458414
GSE24585Down-0.0750455620
GSE37065Down-0.0075502520
GSE28863_A1Up0.4492674339
GSE28863_A2Up0.2253733110
GSE28863_A3Up0.3283422232
GSE28863_A4Down-0.0644164189
GSE48662Up0.2702346630

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-107MIMAT0000104MIRT048298CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.