HCSGD entry for PCSK5

1. General information

Official gene symbolPCSK5
Entrez ID5125
Gene full nameproprotein convertase subtilisin/kexin type 5
Other gene symbolsPC5 PC6 PC6A SPC6
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001822Kidney developmentIMP ISSbiological_process
GO:0002001Renin secretion into blood streamIEPbiological_process
GO:0004252Serine-type endopeptidase activityIDA IEAmolecular_function
GO:0005615Extracellular spaceIBA ISScellular_component
GO:0005794Golgi apparatusISScellular_component
GO:0005796Golgi lumenTAScellular_component
GO:0006465Signal peptide processingIDAbiological_process
GO:0006508ProteolysisIEAbiological_process
GO:0007267Cell-cell signalingTASbiological_process
GO:0007507Heart developmentISSbiological_process
GO:0007566Embryo implantationISSbiological_process
GO:0009952Anterior/posterior pattern specificationIMPbiological_process
GO:0012505Endomembrane systemIEAcellular_component
GO:0016021Integral component of membraneIEAcellular_component
GO:0016485Protein processingIDAbiological_process
GO:0016486Peptide hormone processingIDAbiological_process
GO:0019058Viral life cycleIEP ISSbiological_process
GO:0030141Secretory granuleISScellular_component
GO:0030323Respiratory tube developmentISSbiological_process
GO:0032455Nerve growth factor processingTASbiological_process
GO:0035108Limb morphogenesisISSbiological_process
GO:0042089Cytokine biosynthetic processISSbiological_process
GO:0042277Peptide bindingISSmolecular_function
GO:0043043Peptide biosynthetic processIDAbiological_process
GO:0048011Neurotrophin TRK receptor signaling pathwayTASbiological_process
GO:0048566Embryonic digestive tract developmentIMP ISSbiological_process
GO:0048706Embryonic skeletal system developmentIMP ISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.65869880700.00461011360.99999024730.1374210646

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.3634254909
GSE13712_SHEARDown-1.8339060008
GSE13712_STATICDown-1.2662388431
GSE19018Down-0.8070860456
GSE19899_A1Down-0.1150375305
GSE19899_A2Down-0.5422256814
PubMed_21979375_A1Down-0.7554489956
PubMed_21979375_A2Down-0.5121054157
GSE35957Down-0.2837489982
GSE36640Up1.2771588644
GSE54402Down-2.0460781006
GSE9593Up0.1688379787
GSE43922Down-0.2990458414
GSE24585Down-0.0750455620
GSE37065Down-0.0075502520
GSE28863_A1Up0.4492674339
GSE28863_A2Up0.2253733110
GSE28863_A3Up0.3283422232
GSE28863_A4Down-0.0644164189
GSE48662Up0.2702346630

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-107MIMAT0000104MIRT048298CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.