HCSGD entry for PCSK1

1. General information

Official gene symbolPCSK1
Entrez ID5122
Gene full nameproprotein convertase subtilisin/kexin type 1
Other gene symbolsBMIQ12 NEC1 PC1 PC3 SPC3
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0004252Serine-type endopeptidase activityIBA IEA ISS TASmolecular_function
GO:0005615Extracellular spaceIDA IEAcellular_component
GO:0005794Golgi apparatusIBAcellular_component
GO:0006508ProteolysisIEAbiological_process
GO:0007267Cell-cell signalingTASbiological_process
GO:0008152Metabolic processTASbiological_process
GO:0016486Peptide hormone processingIEA TASbiological_process
GO:0030133Transport vesicleIEAcellular_component
GO:0034774Secretory granule lumenTAScellular_component
GO:0043043Peptide biosynthetic processIEA ISSbiological_process
GO:0044267Cellular protein metabolic processTASbiological_process
GO:0050796Regulation of insulin secretionTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.17475509290.12676295730.82064742190.6852593551

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.3997971761
GSE13712_SHEARDown-0.2124629189
GSE13712_STATICDown-0.1412687787
GSE19018Up0.1237437558
GSE19899_A1Up0.0731033152
GSE19899_A2Up0.0467211806
PubMed_21979375_A1Down-0.2275996487
PubMed_21979375_A2Up0.0998870367
GSE35957Down-0.6619749127
GSE36640Up0.0351805634
GSE54402Down-0.5171859513
GSE9593Down-1.0583833360
GSE43922Up0.0886122367
GSE24585Down-0.1103400095
GSE37065Up0.7266740358
GSE28863_A1Up0.0190394463
GSE28863_A2Up0.0574396443
GSE28863_A3Up0.6535668133
GSE28863_A4Down-0.0019635936
GSE48662Down-0.1920762640

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

Insulin PorkDB00071 BTD00031 | BIOD00031

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-26b-5pMIMAT0000083MIRT029995MicroarrayFunctional MTI (Weak)19088304
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.