HCSGD entry for PCSK1

1. General information

Official gene symbolPCSK1
Entrez ID5122
Gene full nameproprotein convertase subtilisin/kexin type 1
Other gene symbolsBMIQ12 NEC1 PC1 PC3 SPC3
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0004252Serine-type endopeptidase activityIBA IEA ISS TASmolecular_function
GO:0005615Extracellular spaceIDA IEAcellular_component
GO:0005794Golgi apparatusIBAcellular_component
GO:0006508ProteolysisIEAbiological_process
GO:0007267Cell-cell signalingTASbiological_process
GO:0008152Metabolic processTASbiological_process
GO:0016486Peptide hormone processingIEA TASbiological_process
GO:0030133Transport vesicleIEAcellular_component
GO:0034774Secretory granule lumenTAScellular_component
GO:0043043Peptide biosynthetic processIEA ISSbiological_process
GO:0044267Cellular protein metabolic processTASbiological_process
GO:0050796Regulation of insulin secretionTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.17475509290.12676295730.82064742190.6852593551

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.3997971761
GSE13712_SHEARDown-0.2124629189
GSE13712_STATICDown-0.1412687787
GSE19018Up0.1237437558
GSE19899_A1Up0.0731033152
GSE19899_A2Up0.0467211806
PubMed_21979375_A1Down-0.2275996487
PubMed_21979375_A2Up0.0998870367
GSE35957Down-0.6619749127
GSE36640Up0.0351805634
GSE54402Down-0.5171859513
GSE9593Down-1.0583833360
GSE43922Up0.0886122367
GSE24585Down-0.1103400095
GSE37065Up0.7266740358
GSE28863_A1Up0.0190394463
GSE28863_A2Up0.0574396443
GSE28863_A3Up0.6535668133
GSE28863_A4Down-0.0019635936
GSE48662Down-0.1920762640

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

Insulin PorkDB00071 BTD00031 | BIOD00031

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-26b-5pMIMAT0000083MIRT029995MicroarrayFunctional MTI (Weak)19088304
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.