HCSGD entry for PLCE1

1. General information

Official gene symbolPLCE1
Entrez ID51196
Gene full namephospholipase C, epsilon 1
Other gene symbolsNPHS3 PLCE PPLC
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000139Golgi membraneIEAcellular_component
GO:0000187Activation of MAPK activityIDAbiological_process
GO:0001558Regulation of cell growthTASbiological_process
GO:0004435Phosphatidylinositol phospholipase C activityIDAmolecular_function
GO:0004629Phospholipase C activityIDAmolecular_function
GO:0005057Receptor signaling protein activityTASmolecular_function
GO:0005085Guanyl-nucleotide exchange factor activityTASmolecular_function
GO:0005509Calcium ion bindingIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005737CytoplasmIDAcellular_component
GO:0005829CytosolIDAcellular_component
GO:0005886Plasma membraneIDA TAScellular_component
GO:0006644Phospholipid metabolic processICbiological_process
GO:0006651Diacylglycerol biosynthetic processTASbiological_process
GO:0006940Regulation of smooth muscle contractionTASbiological_process
GO:0007010Cytoskeleton organizationNASbiological_process
GO:0007173Epidermal growth factor receptor signaling pathwayNASbiological_process
GO:0007200Phospholipase C-activating G-protein coupled receptor signaling pathwayIDAbiological_process
GO:0007204Positive regulation of cytosolic calcium ion concentrationTASbiological_process
GO:0007205Protein kinase C-activating G-protein coupled receptor signaling pathwayNASbiological_process
GO:0007265Ras protein signal transductionTASbiological_process
GO:0007507Heart developmentTASbiological_process
GO:0008277Regulation of G-protein coupled receptor protein signaling pathwayIDAbiological_process
GO:0008283Cell proliferationNASbiological_process
GO:0016042Lipid catabolic processIEAbiological_process
GO:0017016Ras GTPase bindingTASmolecular_function
GO:0019722Calcium-mediated signalingNAS TASbiological_process
GO:0019899Enzyme bindingIPImolecular_function
GO:0032835Glomerulus developmentIMPbiological_process
GO:0043087Regulation of GTPase activityTASbiological_process
GO:0043647Inositol phosphate metabolic processTASbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
GO:0045859Regulation of protein kinase activityIDAbiological_process
GO:0046578Regulation of Ras protein signal transductionIDAbiological_process
GO:0048016Inositol phosphate-mediated signalingTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.91846655900.02387431710.99999024730.2981005218

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0013183214
GSE13712_SHEARDown-0.0935746608
GSE13712_STATICUp0.0279624790
GSE19018Up0.0508385502
GSE19899_A1Down-0.0356330336
GSE19899_A2Down-0.5793441184
PubMed_21979375_A1Down-0.3309719573
PubMed_21979375_A2Down-0.1960037223
GSE35957Up0.2840148398
GSE36640Down-0.4713068520
GSE54402Down-0.0129954244
GSE9593Up0.2431055425
GSE43922Down-1.6364275005
GSE24585Down-0.2975610937
GSE37065Down-0.4726751277
GSE28863_A1Up0.1484459800
GSE28863_A2Down-0.5833340829
GSE28863_A3Down-0.3038299783
GSE28863_A4Down-0.2316874225
GSE48662Up0.2119991695

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-335-5pMIMAT0000765MIRT017291MicroarrayFunctional MTI (Weak)18185580
hsa-miR-215-5pMIMAT0000272MIRT024850MicroarrayFunctional MTI (Weak)19074876
hsa-miR-192-5pMIMAT0000222MIRT026288MicroarrayFunctional MTI (Weak)19074876
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.