HCSGD entry for PLCE1

1. General information

Official gene symbolPLCE1
Entrez ID51196
Gene full namephospholipase C, epsilon 1
Other gene symbolsNPHS3 PLCE PPLC
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000139Golgi membraneIEAcellular_component
GO:0000187Activation of MAPK activityIDAbiological_process
GO:0001558Regulation of cell growthTASbiological_process
GO:0004435Phosphatidylinositol phospholipase C activityIDAmolecular_function
GO:0004629Phospholipase C activityIDAmolecular_function
GO:0005057Receptor signaling protein activityTASmolecular_function
GO:0005085Guanyl-nucleotide exchange factor activityTASmolecular_function
GO:0005509Calcium ion bindingIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005737CytoplasmIDAcellular_component
GO:0005829CytosolIDAcellular_component
GO:0005886Plasma membraneIDA TAScellular_component
GO:0006644Phospholipid metabolic processICbiological_process
GO:0006651Diacylglycerol biosynthetic processTASbiological_process
GO:0006940Regulation of smooth muscle contractionTASbiological_process
GO:0007010Cytoskeleton organizationNASbiological_process
GO:0007173Epidermal growth factor receptor signaling pathwayNASbiological_process
GO:0007200Phospholipase C-activating G-protein coupled receptor signaling pathwayIDAbiological_process
GO:0007204Positive regulation of cytosolic calcium ion concentrationTASbiological_process
GO:0007205Protein kinase C-activating G-protein coupled receptor signaling pathwayNASbiological_process
GO:0007265Ras protein signal transductionTASbiological_process
GO:0007507Heart developmentTASbiological_process
GO:0008277Regulation of G-protein coupled receptor protein signaling pathwayIDAbiological_process
GO:0008283Cell proliferationNASbiological_process
GO:0016042Lipid catabolic processIEAbiological_process
GO:0017016Ras GTPase bindingTASmolecular_function
GO:0019722Calcium-mediated signalingNAS TASbiological_process
GO:0019899Enzyme bindingIPImolecular_function
GO:0032835Glomerulus developmentIMPbiological_process
GO:0043087Regulation of GTPase activityTASbiological_process
GO:0043647Inositol phosphate metabolic processTASbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
GO:0045859Regulation of protein kinase activityIDAbiological_process
GO:0046578Regulation of Ras protein signal transductionIDAbiological_process
GO:0048016Inositol phosphate-mediated signalingTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.91846655900.02387431710.99999024730.2981005218

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0013183214
GSE13712_SHEARDown-0.0935746608
GSE13712_STATICUp0.0279624790
GSE19018Up0.0508385502
GSE19899_A1Down-0.0356330336
GSE19899_A2Down-0.5793441184
PubMed_21979375_A1Down-0.3309719573
PubMed_21979375_A2Down-0.1960037223
GSE35957Up0.2840148398
GSE36640Down-0.4713068520
GSE54402Down-0.0129954244
GSE9593Up0.2431055425
GSE43922Down-1.6364275005
GSE24585Down-0.2975610937
GSE37065Down-0.4726751277
GSE28863_A1Up0.1484459800
GSE28863_A2Down-0.5833340829
GSE28863_A3Down-0.3038299783
GSE28863_A4Down-0.2316874225
GSE48662Up0.2119991695

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-335-5pMIMAT0000765MIRT017291MicroarrayFunctional MTI (Weak)18185580
hsa-miR-215-5pMIMAT0000272MIRT024850MicroarrayFunctional MTI (Weak)19074876
hsa-miR-192-5pMIMAT0000222MIRT026288MicroarrayFunctional MTI (Weak)19074876
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.