HCSGD entry for LEF1

1. General information

Official gene symbolLEF1
Entrez ID51176
Gene full namelymphoid enhancer-binding factor 1
Other gene symbolsLEF-1 TCF10 TCF1ALPHA TCF7L3
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000122Negative regulation of transcription from RNA polymerase II promoterIEAbiological_process
GO:0000977RNA polymerase II regulatory region sequence-specific DNA bindingIDAmolecular_function
GO:0001228RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcriptionIMPmolecular_function
GO:0001569Patterning of blood vesselsIBAbiological_process
GO:0001649Osteoblast differentiationIEPbiological_process
GO:0001755Neural crest cell migrationIBAbiological_process
GO:0001756SomitogenesisIBAbiological_process
GO:0001837Epithelial to mesenchymal transitionISSbiological_process
GO:0002040Sprouting angiogenesisIBAbiological_process
GO:0003677DNA bindingISSmolecular_function
GO:0003682Chromatin bindingIBAmolecular_function
GO:0003700Sequence-specific DNA binding transcription factor activityIDAmolecular_function
GO:0003705RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activityIBAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIC IDAcellular_component
GO:0005667Transcription factor complexIDAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0006366Transcription from RNA polymerase II promoterIDAbiological_process
GO:0008013Beta-catenin bindingIDA IPI TASmolecular_function
GO:0008134Transcription factor bindingIEAmolecular_function
GO:0008284Positive regulation of cell proliferationIDAbiological_process
GO:0008301DNA binding, bendingISSmolecular_function
GO:0010628Positive regulation of gene expressionIDAbiological_process
GO:0010718Positive regulation of epithelial to mesenchymal transitionIMPbiological_process
GO:0016055Wnt signaling pathwayIDA IEAbiological_process
GO:0016202Regulation of striated muscle tissue developmentIBAbiological_process
GO:0021542Dentate gyrus developmentIBAbiological_process
GO:0021854Hypothalamus developmentIBAbiological_process
GO:0021861Forebrain radial glial cell differentiationIBAbiological_process
GO:0021873Forebrain neuroblast divisionIBAbiological_process
GO:0021879Forebrain neuron differentiationIBAbiological_process
GO:0021943Formation of radial glial scaffoldsIBAbiological_process
GO:0022407Regulation of cell-cell adhesionIEAbiological_process
GO:0022408Negative regulation of cell-cell adhesionIDAbiological_process
GO:0022409Positive regulation of cell-cell adhesionIDAbiological_process
GO:0030223Neutrophil differentiationIMPbiological_process
GO:0030284Estrogen receptor activityIDAmolecular_function
GO:0030307Positive regulation of cell growthIMPbiological_process
GO:0030326Embryonic limb morphogenesisIBAbiological_process
GO:0030331Estrogen receptor bindingIDAmolecular_function
GO:0030335Positive regulation of cell migrationIDA IMPbiological_process
GO:0030509BMP signaling pathwayIBAbiological_process
GO:0030854Positive regulation of granulocyte differentiationIDA IMPbiological_process
GO:0030879Mammary gland developmentIBAbiological_process
GO:0032696Negative regulation of interleukin-13 productionIDAbiological_process
GO:0032713Negative regulation of interleukin-4 productionIDAbiological_process
GO:0032714Negative regulation of interleukin-5 productionIDAbiological_process
GO:0032993Protein-DNA complexIDAcellular_component
GO:0033153T cell receptor V(D)J recombinationIEAbiological_process
GO:0035326Enhancer bindingIDAmolecular_function
GO:0042100B cell proliferationIBAbiological_process
GO:0042393Histone bindingIPImolecular_function
GO:0042475Odontogenesis of dentin-containing toothIEAbiological_process
GO:0043027Cysteine-type endopeptidase inhibitor activity involved in apoptotic processIMPmolecular_function
GO:0043066Negative regulation of apoptotic processIMPbiological_process
GO:0043154Negative regulation of cysteine-type endopeptidase activity involved in apoptotic processIMPbiological_process
GO:0043392Negative regulation of DNA bindingIDAbiological_process
GO:0043401Steroid hormone mediated signaling pathwayIDAbiological_process
GO:0043565Sequence-specific DNA bindingIDAmolecular_function
GO:0043586Tongue developmentIEAbiological_process
GO:0043923Positive regulation by host of viral transcriptionIDAbiological_process
GO:0043966Histone H3 acetylationIMPbiological_process
GO:0043967Histone H4 acetylationIMPbiological_process
GO:0044212Transcription regulatory region DNA bindingIDAmolecular_function
GO:0045063T-helper 1 cell differentiationISSbiological_process
GO:0045295Gamma-catenin bindingIPImolecular_function
GO:0045843Negative regulation of striated muscle tissue developmentIEAbiological_process
GO:0045892Negative regulation of transcription, DNA-templatedIDA IMPbiological_process
GO:0045893Positive regulation of transcription, DNA-templatedIDA IMPbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIDA IMPbiological_process
GO:0046632Alpha-beta T cell differentiationIBAbiological_process
GO:0048069Eye pigmentationIBAbiological_process
GO:0048341Paraxial mesoderm formationIBAbiological_process
GO:0048747Muscle fiber developmentIBAbiological_process
GO:0050909Sensory perception of tasteIEAbiological_process
GO:0060021Palate developmentISSbiological_process
GO:0060033Anatomical structure regressionIEAbiological_process
GO:0060070Canonical Wnt signaling pathwayIDA IMPbiological_process
GO:0060325Face morphogenesisIBAbiological_process
GO:0060326Cell chemotaxisIDAbiological_process
GO:0060561Apoptotic process involved in morphogenesisIBAbiological_process
GO:0060710Chorio-allantoic fusionIBAbiological_process
GO:0061153Trachea gland developmentIBAbiological_process
GO:0070016Armadillo repeat domain bindingIPImolecular_function
GO:0070742C2H2 zinc finger domain bindingIPImolecular_function
GO:0071345Cellular response to cytokine stimulusIMPbiological_process
GO:0071353Cellular response to interleukin-4IDAbiological_process
GO:0071864Positive regulation of cell proliferation in bone marrowIMPbiological_process
GO:0071866Negative regulation of apoptotic process in bone marrowIMPbiological_process
GO:0071895Odontoblast differentiationIBAbiological_process
GO:0071899Negative regulation of estrogen receptor bindingIDAbiological_process
GO:0090068Positive regulation of cell cycle processIDAbiological_process
GO:0090090Negative regulation of canonical Wnt signaling pathwayIMPbiological_process
GO:1902262Apoptotic process involved in patterning of blood vesselsIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.14105299570.29640036090.75429823241.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0129798907
GSE13712_SHEARDown-0.1261545837
GSE13712_STATICUp0.0243450460
GSE19018Down-0.9745988090
GSE19899_A1Up0.1878121746
GSE19899_A2Down-0.0302925505
PubMed_21979375_A1Up0.3875533364
PubMed_21979375_A2Up0.4805816922
GSE35957Down-0.1979744172
GSE36640Up0.2627654574
GSE54402Up0.7867869669
GSE9593Down-0.7253057996
GSE43922Up1.4453864571
GSE24585Down-0.5083328367
GSE37065Up0.4503846813
GSE28863_A1Down-0.0856382945
GSE28863_A2Down-0.2239188207
GSE28863_A3Up0.1030107055
GSE28863_A4Up0.0026055471
GSE48662Up0.0788204924

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-193b-3pMIMAT0002819MIRT016343MicroarrayFunctional MTI (Weak)20304954
hsa-miR-34a-5pMIMAT0000255MIRT025380Reporter assay;ProteomicsFunctional MTI21566225
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.