HCSGD entry for LEF1

1. General information

Official gene symbolLEF1
Entrez ID51176
Gene full namelymphoid enhancer-binding factor 1
Other gene symbolsLEF-1 TCF10 TCF1ALPHA TCF7L3
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000122Negative regulation of transcription from RNA polymerase II promoterIEAbiological_process
GO:0000977RNA polymerase II regulatory region sequence-specific DNA bindingIDAmolecular_function
GO:0001228RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcriptionIMPmolecular_function
GO:0001569Patterning of blood vesselsIBAbiological_process
GO:0001649Osteoblast differentiationIEPbiological_process
GO:0001755Neural crest cell migrationIBAbiological_process
GO:0001756SomitogenesisIBAbiological_process
GO:0001837Epithelial to mesenchymal transitionISSbiological_process
GO:0002040Sprouting angiogenesisIBAbiological_process
GO:0003677DNA bindingISSmolecular_function
GO:0003682Chromatin bindingIBAmolecular_function
GO:0003700Sequence-specific DNA binding transcription factor activityIDAmolecular_function
GO:0003705RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activityIBAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIC IDAcellular_component
GO:0005667Transcription factor complexIDAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0006366Transcription from RNA polymerase II promoterIDAbiological_process
GO:0008013Beta-catenin bindingIDA IPI TASmolecular_function
GO:0008134Transcription factor bindingIEAmolecular_function
GO:0008284Positive regulation of cell proliferationIDAbiological_process
GO:0008301DNA binding, bendingISSmolecular_function
GO:0010628Positive regulation of gene expressionIDAbiological_process
GO:0010718Positive regulation of epithelial to mesenchymal transitionIMPbiological_process
GO:0016055Wnt signaling pathwayIDA IEAbiological_process
GO:0016202Regulation of striated muscle tissue developmentIBAbiological_process
GO:0021542Dentate gyrus developmentIBAbiological_process
GO:0021854Hypothalamus developmentIBAbiological_process
GO:0021861Forebrain radial glial cell differentiationIBAbiological_process
GO:0021873Forebrain neuroblast divisionIBAbiological_process
GO:0021879Forebrain neuron differentiationIBAbiological_process
GO:0021943Formation of radial glial scaffoldsIBAbiological_process
GO:0022407Regulation of cell-cell adhesionIEAbiological_process
GO:0022408Negative regulation of cell-cell adhesionIDAbiological_process
GO:0022409Positive regulation of cell-cell adhesionIDAbiological_process
GO:0030223Neutrophil differentiationIMPbiological_process
GO:0030284Estrogen receptor activityIDAmolecular_function
GO:0030307Positive regulation of cell growthIMPbiological_process
GO:0030326Embryonic limb morphogenesisIBAbiological_process
GO:0030331Estrogen receptor bindingIDAmolecular_function
GO:0030335Positive regulation of cell migrationIDA IMPbiological_process
GO:0030509BMP signaling pathwayIBAbiological_process
GO:0030854Positive regulation of granulocyte differentiationIDA IMPbiological_process
GO:0030879Mammary gland developmentIBAbiological_process
GO:0032696Negative regulation of interleukin-13 productionIDAbiological_process
GO:0032713Negative regulation of interleukin-4 productionIDAbiological_process
GO:0032714Negative regulation of interleukin-5 productionIDAbiological_process
GO:0032993Protein-DNA complexIDAcellular_component
GO:0033153T cell receptor V(D)J recombinationIEAbiological_process
GO:0035326Enhancer bindingIDAmolecular_function
GO:0042100B cell proliferationIBAbiological_process
GO:0042393Histone bindingIPImolecular_function
GO:0042475Odontogenesis of dentin-containing toothIEAbiological_process
GO:0043027Cysteine-type endopeptidase inhibitor activity involved in apoptotic processIMPmolecular_function
GO:0043066Negative regulation of apoptotic processIMPbiological_process
GO:0043154Negative regulation of cysteine-type endopeptidase activity involved in apoptotic processIMPbiological_process
GO:0043392Negative regulation of DNA bindingIDAbiological_process
GO:0043401Steroid hormone mediated signaling pathwayIDAbiological_process
GO:0043565Sequence-specific DNA bindingIDAmolecular_function
GO:0043586Tongue developmentIEAbiological_process
GO:0043923Positive regulation by host of viral transcriptionIDAbiological_process
GO:0043966Histone H3 acetylationIMPbiological_process
GO:0043967Histone H4 acetylationIMPbiological_process
GO:0044212Transcription regulatory region DNA bindingIDAmolecular_function
GO:0045063T-helper 1 cell differentiationISSbiological_process
GO:0045295Gamma-catenin bindingIPImolecular_function
GO:0045843Negative regulation of striated muscle tissue developmentIEAbiological_process
GO:0045892Negative regulation of transcription, DNA-templatedIDA IMPbiological_process
GO:0045893Positive regulation of transcription, DNA-templatedIDA IMPbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIDA IMPbiological_process
GO:0046632Alpha-beta T cell differentiationIBAbiological_process
GO:0048069Eye pigmentationIBAbiological_process
GO:0048341Paraxial mesoderm formationIBAbiological_process
GO:0048747Muscle fiber developmentIBAbiological_process
GO:0050909Sensory perception of tasteIEAbiological_process
GO:0060021Palate developmentISSbiological_process
GO:0060033Anatomical structure regressionIEAbiological_process
GO:0060070Canonical Wnt signaling pathwayIDA IMPbiological_process
GO:0060325Face morphogenesisIBAbiological_process
GO:0060326Cell chemotaxisIDAbiological_process
GO:0060561Apoptotic process involved in morphogenesisIBAbiological_process
GO:0060710Chorio-allantoic fusionIBAbiological_process
GO:0061153Trachea gland developmentIBAbiological_process
GO:0070016Armadillo repeat domain bindingIPImolecular_function
GO:0070742C2H2 zinc finger domain bindingIPImolecular_function
GO:0071345Cellular response to cytokine stimulusIMPbiological_process
GO:0071353Cellular response to interleukin-4IDAbiological_process
GO:0071864Positive regulation of cell proliferation in bone marrowIMPbiological_process
GO:0071866Negative regulation of apoptotic process in bone marrowIMPbiological_process
GO:0071895Odontoblast differentiationIBAbiological_process
GO:0071899Negative regulation of estrogen receptor bindingIDAbiological_process
GO:0090068Positive regulation of cell cycle processIDAbiological_process
GO:0090090Negative regulation of canonical Wnt signaling pathwayIMPbiological_process
GO:1902262Apoptotic process involved in patterning of blood vesselsIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.14105299570.29640036090.75429823241.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0129798907
GSE13712_SHEARDown-0.1261545837
GSE13712_STATICUp0.0243450460
GSE19018Down-0.9745988090
GSE19899_A1Up0.1878121746
GSE19899_A2Down-0.0302925505
PubMed_21979375_A1Up0.3875533364
PubMed_21979375_A2Up0.4805816922
GSE35957Down-0.1979744172
GSE36640Up0.2627654574
GSE54402Up0.7867869669
GSE9593Down-0.7253057996
GSE43922Up1.4453864571
GSE24585Down-0.5083328367
GSE37065Up0.4503846813
GSE28863_A1Down-0.0856382945
GSE28863_A2Down-0.2239188207
GSE28863_A3Up0.1030107055
GSE28863_A4Up0.0026055471
GSE48662Up0.0788204924

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-193b-3pMIMAT0002819MIRT016343MicroarrayFunctional MTI (Weak)20304954
hsa-miR-34a-5pMIMAT0000255MIRT025380Reporter assay;ProteomicsFunctional MTI21566225
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.