HCSGD entry for IRAK4

1. General information

Official gene symbolIRAK4
Entrez ID51135
Gene full nameinterleukin-1 receptor-associated kinase 4
Other gene symbolsIPD1 IRAK-4 NY-REN-64 REN64
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000287Magnesium ion bindingIEAmolecular_function
GO:0001816Cytokine productionIEAbiological_process
GO:0002224Toll-like receptor signaling pathwayTASbiological_process
GO:0002755MyD88-dependent toll-like receptor signaling pathwayTASbiological_process
GO:0004672Protein kinase activityEXPmolecular_function
GO:0004674Protein serine/threonine kinase activityEXP TASmolecular_function
GO:0005149Interleukin-1 receptor bindingIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005829CytosolTAScellular_component
GO:0005886Plasma membraneTAScellular_component
GO:0007254JNK cascadeIEAbiological_process
GO:0010008Endosome membraneTAScellular_component
GO:0019221Cytokine-mediated signaling pathwayIEAbiological_process
GO:0034134Toll-like receptor 2 signaling pathwayTASbiological_process
GO:0034142Toll-like receptor 4 signaling pathwayTASbiological_process
GO:0034146Toll-like receptor 5 signaling pathwayTASbiological_process
GO:0034162Toll-like receptor 9 signaling pathwayTASbiological_process
GO:0034166Toll-like receptor 10 signaling pathwayTASbiological_process
GO:0038123Toll-like receptor TLR1:TLR2 signaling pathwayTASbiological_process
GO:0038124Toll-like receptor TLR6:TLR2 signaling pathwayTASbiological_process
GO:0045087Innate immune responseTASbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIEAbiological_process
GO:0048661Positive regulation of smooth muscle cell proliferationIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.92733536720.00695502070.99999024730.1665724295

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0809993978
GSE13712_SHEARDown-0.5548228830
GSE13712_STATICDown-0.0465268797
GSE19018Up0.1966972819
GSE19899_A1Down-0.2867258764
GSE19899_A2Down-1.0606210571
PubMed_21979375_A1Down-1.0300104799
PubMed_21979375_A2Down-1.5071065884
GSE35957Up0.1294987565
GSE36640Up0.0724434980
GSE54402Down-0.6330324196
GSE9593Down-0.0018588981
GSE43922Down-1.2622897720
GSE24585Up0.3969592065
GSE37065Up0.0894217878
GSE28863_A1Down-0.2838854226
GSE28863_A2Down-0.2595087256
GSE28863_A3Down-1.1411549870
GSE28863_A4Up0.1822372736
GSE48662Down-0.0585134577

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

1-(3-HYDROXYPROPYL)-2-[(3-NITROBENZOYL)AMINO]-1H-BENZIMIDAZOL-5-YL PIVALATEDB08590 -

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-215-5pMIMAT0000272MIRT024734MicroarrayFunctional MTI (Weak)19074876
hsa-miR-192-5pMIMAT0000222MIRT026168MicroarrayFunctional MTI (Weak)19074876
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.