HCSGD entry for IRAK4

1. General information

Official gene symbolIRAK4
Entrez ID51135
Gene full nameinterleukin-1 receptor-associated kinase 4
Other gene symbolsIPD1 IRAK-4 NY-REN-64 REN64
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000287Magnesium ion bindingIEAmolecular_function
GO:0001816Cytokine productionIEAbiological_process
GO:0002224Toll-like receptor signaling pathwayTASbiological_process
GO:0002755MyD88-dependent toll-like receptor signaling pathwayTASbiological_process
GO:0004672Protein kinase activityEXPmolecular_function
GO:0004674Protein serine/threonine kinase activityEXP TASmolecular_function
GO:0005149Interleukin-1 receptor bindingIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005829CytosolTAScellular_component
GO:0005886Plasma membraneTAScellular_component
GO:0007254JNK cascadeIEAbiological_process
GO:0010008Endosome membraneTAScellular_component
GO:0019221Cytokine-mediated signaling pathwayIEAbiological_process
GO:0034134Toll-like receptor 2 signaling pathwayTASbiological_process
GO:0034142Toll-like receptor 4 signaling pathwayTASbiological_process
GO:0034146Toll-like receptor 5 signaling pathwayTASbiological_process
GO:0034162Toll-like receptor 9 signaling pathwayTASbiological_process
GO:0034166Toll-like receptor 10 signaling pathwayTASbiological_process
GO:0038123Toll-like receptor TLR1:TLR2 signaling pathwayTASbiological_process
GO:0038124Toll-like receptor TLR6:TLR2 signaling pathwayTASbiological_process
GO:0045087Innate immune responseTASbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIEAbiological_process
GO:0048661Positive regulation of smooth muscle cell proliferationIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.92733536720.00695502070.99999024730.1665724295

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0809993978
GSE13712_SHEARDown-0.5548228830
GSE13712_STATICDown-0.0465268797
GSE19018Up0.1966972819
GSE19899_A1Down-0.2867258764
GSE19899_A2Down-1.0606210571
PubMed_21979375_A1Down-1.0300104799
PubMed_21979375_A2Down-1.5071065884
GSE35957Up0.1294987565
GSE36640Up0.0724434980
GSE54402Down-0.6330324196
GSE9593Down-0.0018588981
GSE43922Down-1.2622897720
GSE24585Up0.3969592065
GSE37065Up0.0894217878
GSE28863_A1Down-0.2838854226
GSE28863_A2Down-0.2595087256
GSE28863_A3Down-1.1411549870
GSE28863_A4Up0.1822372736
GSE48662Down-0.0585134577

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

1-(3-HYDROXYPROPYL)-2-[(3-NITROBENZOYL)AMINO]-1H-BENZIMIDAZOL-5-YL PIVALATEDB08590 -

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-215-5pMIMAT0000272MIRT024734MicroarrayFunctional MTI (Weak)19074876
hsa-miR-192-5pMIMAT0000222MIRT026168MicroarrayFunctional MTI (Weak)19074876
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.