HCSGD entry for PAX3
1. General information
| Official gene symbol | PAX3 |
|---|---|
| Entrez ID | 5077 |
| Gene full name | paired box 3 |
| Other gene symbols | CDHS HUP2 WS1 WS3 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000122 | Negative regulation of transcription from RNA polymerase II promoter | IEA | biological_process |
| GO:0001755 | Neural crest cell migration | IEA | biological_process |
| GO:0001843 | Neural tube closure | IEA | biological_process |
| GO:0003682 | Chromatin binding | IEA | molecular_function |
| GO:0003700 | Sequence-specific DNA binding transcription factor activity | TAS | molecular_function |
| GO:0003705 | RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IEA | cellular_component |
| GO:0006366 | Transcription from RNA polymerase II promoter | TAS | biological_process |
| GO:0006915 | Apoptotic process | TAS | biological_process |
| GO:0007507 | Heart development | IEA | biological_process |
| GO:0007517 | Muscle organ development | IEA | biological_process |
| GO:0007605 | Sensory perception of sound | TAS | biological_process |
| GO:0008283 | Cell proliferation | IEA | biological_process |
| GO:0008284 | Positive regulation of cell proliferation | IEA | biological_process |
| GO:0009887 | Organ morphogenesis | TAS | biological_process |
| GO:0014807 | Regulation of somitogenesis | IEA | biological_process |
| GO:0021527 | Spinal cord association neuron differentiation | IEA | biological_process |
| GO:0043565 | Sequence-specific DNA binding | IDA | molecular_function |
| GO:0045893 | Positive regulation of transcription, DNA-templated | IDA | biological_process |
| GO:0045944 | Positive regulation of transcription from RNA polymerase II promoter | IDA | biological_process |
| GO:0048066 | Developmental pigmentation | IEA | biological_process |
| GO:0048663 | Neuron fate commitment | IEA | biological_process |
| GO:0060594 | Mammary gland specification | IEA | biological_process |
| GO:0071837 | HMG box domain binding | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.8547319745 | 0.7657671783 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0353403136 |
| GSE13712_SHEAR | Down | -0.0001417257 |
| GSE13712_STATIC | Down | -0.0326097031 |
| GSE19018 | Up | 0.0188551175 |
| GSE19899_A1 | Up | 0.0006469338 |
| GSE19899_A2 | Up | 0.2166411141 |
| PubMed_21979375_A1 | Down | -0.0633455325 |
| PubMed_21979375_A2 | Down | -0.0933530255 |
| GSE35957 | Up | 0.1073796090 |
| GSE36640 | Up | 0.0332997161 |
| GSE54402 | Up | 0.0771264725 |
| GSE9593 | Up | 0.0764117824 |
| GSE43922 | Up | 0.0146693892 |
| GSE24585 | Up | 0.1138957544 |
| GSE37065 | Down | -0.0082708628 |
| GSE28863_A1 | Down | -0.1389223421 |
| GSE28863_A2 | Up | 0.4076595853 |
| GSE28863_A3 | Down | -0.3810004998 |
| GSE28863_A4 | Down | -0.1076413643 |
| GSE48662 | Down | -0.0284342685 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-27a-3p | MIMAT0000084 | MIRT006521 | Luciferase reporter assay//Reporter assay;Other | Functional MTI | 19666532 |
| hsa-miR-27b-3p | MIMAT0000419 | MIRT006522 | Luciferase reporter assay//Reporter assay;Western blot;Other | Functional MTI | 19666532 |
| hsa-miR-1 | MIMAT0000416 | MIRT004670 | ChIP-seq//Immunoblot//Luciferase reporter assay//qRT-PCR//Western blot | Functional MTI | 20956382 |
| hsa-miR-1 | MIMAT0000416 | MIRT004670 | Microarray | Functional MTI (Weak) | 18668037 |
| hsa-miR-206 | MIMAT0000462 | MIRT004671 | ChIP-seq//Immunoblot//Luciferase reporter assay//qRT-PCR//Western blot | Functional MTI | 20956382 |
| hsa-miR-324-5p | MIMAT0000761 | MIRT043036 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7e-5p | MIMAT0000066 | MIRT051642 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7b-5p | MIMAT0000063 | MIRT052081 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 22829758 | These include COL4A3, CFLAR, GULP1, PDCD1, CASP10, PAX3, BOK, HSPD1, PITX2, and PML |
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