HCSGD entry for PAX3

1. General information

Official gene symbolPAX3
Entrez ID5077
Gene full namepaired box 3
Other gene symbolsCDHS HUP2 WS1 WS3
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000122Negative regulation of transcription from RNA polymerase II promoterIEAbiological_process
GO:0001755Neural crest cell migrationIEAbiological_process
GO:0001843Neural tube closureIEAbiological_process
GO:0003682Chromatin bindingIEAmolecular_function
GO:0003700Sequence-specific DNA binding transcription factor activityTASmolecular_function
GO:0003705RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activityIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIEAcellular_component
GO:0006366Transcription from RNA polymerase II promoterTASbiological_process
GO:0006915Apoptotic processTASbiological_process
GO:0007507Heart developmentIEAbiological_process
GO:0007517Muscle organ developmentIEAbiological_process
GO:0007605Sensory perception of soundTASbiological_process
GO:0008283Cell proliferationIEAbiological_process
GO:0008284Positive regulation of cell proliferationIEAbiological_process
GO:0009887Organ morphogenesisTASbiological_process
GO:0014807Regulation of somitogenesisIEAbiological_process
GO:0021527Spinal cord association neuron differentiationIEAbiological_process
GO:0043565Sequence-specific DNA bindingIDAmolecular_function
GO:0045893Positive regulation of transcription, DNA-templatedIDAbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIDAbiological_process
GO:0048066Developmental pigmentationIEAbiological_process
GO:0048663Neuron fate commitmentIEAbiological_process
GO:0060594Mammary gland specificationIEAbiological_process
GO:0071837HMG box domain bindingIEAmolecular_function
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.85473197450.76576717830.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0353403136
GSE13712_SHEARDown-0.0001417257
GSE13712_STATICDown-0.0326097031
GSE19018Up0.0188551175
GSE19899_A1Up0.0006469338
GSE19899_A2Up0.2166411141
PubMed_21979375_A1Down-0.0633455325
PubMed_21979375_A2Down-0.0933530255
GSE35957Up0.1073796090
GSE36640Up0.0332997161
GSE54402Up0.0771264725
GSE9593Up0.0764117824
GSE43922Up0.0146693892
GSE24585Up0.1138957544
GSE37065Down-0.0082708628
GSE28863_A1Down-0.1389223421
GSE28863_A2Up0.4076595853
GSE28863_A3Down-0.3810004998
GSE28863_A4Down-0.1076413643
GSE48662Down-0.0284342685

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-27a-3pMIMAT0000084MIRT006521Luciferase reporter assay//Reporter assay;OtherFunctional MTI19666532
hsa-miR-27b-3pMIMAT0000419MIRT006522Luciferase reporter assay//Reporter assay;Western blot;OtherFunctional MTI19666532
hsa-miR-1MIMAT0000416MIRT004670ChIP-seq//Immunoblot//Luciferase reporter assay//qRT-PCR//Western blotFunctional MTI20956382
hsa-miR-1MIMAT0000416MIRT004670MicroarrayFunctional MTI (Weak)18668037
hsa-miR-206MIMAT0000462MIRT004671ChIP-seq//Immunoblot//Luciferase reporter assay//qRT-PCR//Western blotFunctional MTI20956382
hsa-miR-324-5pMIMAT0000761MIRT043036CLASHFunctional MTI (Weak)23622248
hsa-let-7e-5pMIMAT0000066MIRT051642CLASHFunctional MTI (Weak)23622248
hsa-let-7b-5pMIMAT0000063MIRT052081CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

22829758These include COL4A3, CFLAR, GULP1, PDCD1, CASP10, PAX3, BOK, HSPD1, PITX2, and PML
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