HCSGD entry for P2RX1

1. General information

Official gene symbolP2RX1
Entrez ID5023
Gene full namepurinergic receptor P2X, ligand-gated ion channel, 1
Other gene symbolsP2X1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001614Purinergic nucleotide receptor activityIDA IEAmolecular_function
GO:0002554Serotonin secretion by plateletIEAbiological_process
GO:0003056Regulation of vascular smooth muscle contractionIEAbiological_process
GO:0004931Extracellular ATP-gated cation channel activityIBAmolecular_function
GO:0005216Ion channel activityIEAmolecular_function
GO:0005261Cation channel activityIDAmolecular_function
GO:0005262Calcium channel activityTASmolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005886Plasma membraneTAScellular_component
GO:0005887Integral component of plasma membraneTAScellular_component
GO:0006810TransportTASbiological_process
GO:0006811Ion transportIDAbiological_process
GO:0006812Cation transportIBAbiological_process
GO:0006919Activation of cysteine-type endopeptidase activity involved in apoptotic processIEAbiological_process
GO:0007165Signal transductionTASbiological_process
GO:0007320InseminationIEAbiological_process
GO:0007596Blood coagulationTASbiological_process
GO:0008144Drug bindingIEAmolecular_function
GO:0008217Regulation of blood pressureIEAbiological_process
GO:0008270Zinc ion bindingIEAmolecular_function
GO:0016020MembraneIEAcellular_component
GO:0019228Neuronal action potentialIEAbiological_process
GO:0030001Metal ion transportTASbiological_process
GO:0030168Platelet activationIEAbiological_process
GO:0031240External side of cell outer membraneIEAcellular_component
GO:0033198Response to ATPIEAbiological_process
GO:0034220Ion transmembrane transportIBA IDA TASbiological_process
GO:0035249Synaptic transmission, glutamatergicIEAbiological_process
GO:0035587Purinergic receptor signaling pathwayIDAbiological_process
GO:0035590Purinergic nucleotide receptor signaling pathwayIDAbiological_process
GO:0042310VasoconstrictionIEAbiological_process
GO:0043005Neuron projectionIEAcellular_component
GO:0043234Protein complexIEAcellular_component
GO:0043270Positive regulation of ion transportIEAbiological_process
GO:0045121Membrane raftIEAcellular_component
GO:0045211Postsynaptic membraneIEAcellular_component
GO:0046513Ceramide biosynthetic processIEAbiological_process
GO:0051260Protein homooligomerizationIEAbiological_process
GO:0051291Protein heterooligomerizationIEAbiological_process
GO:0051924Regulation of calcium ion transportIEAbiological_process
GO:0055085Transmembrane transportIBA IDA TASbiological_process
GO:0070588Calcium ion transmembrane transportTASbiological_process
GO:0072511Divalent inorganic cation transportTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.48228144450.84773356260.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0087225030
GSE13712_SHEARDown-0.4469544180
GSE13712_STATICUp0.1666171073
GSE19018Down-0.0025909199
GSE19899_A1Down-0.0407656851
GSE19899_A2Down-0.0907834756
PubMed_21979375_A1Up0.0780009191
PubMed_21979375_A2Down-0.2744910353
GSE35957Up0.4033998867
GSE36640Up0.1887022683
GSE54402Up0.0589625959
GSE9593Down-0.1393096103
GSE43922Up0.1094582940
GSE24585Up0.1548746757
GSE37065Down-0.0383753838
GSE28863_A1Up0.0101463519
GSE28863_A2Up0.0155420202
GSE28863_A3Up0.3190383816
GSE28863_A4Up0.1587450032
GSE48662Up0.1571840428

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-335-5pMIMAT0000765MIRT017667MicroarrayFunctional MTI (Weak)18185580
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.