HCSGD entry for P2RX1

1. General information

Official gene symbolP2RX1
Entrez ID5023
Gene full namepurinergic receptor P2X, ligand-gated ion channel, 1
Other gene symbolsP2X1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001614Purinergic nucleotide receptor activityIDA IEAmolecular_function
GO:0002554Serotonin secretion by plateletIEAbiological_process
GO:0003056Regulation of vascular smooth muscle contractionIEAbiological_process
GO:0004931Extracellular ATP-gated cation channel activityIBAmolecular_function
GO:0005216Ion channel activityIEAmolecular_function
GO:0005261Cation channel activityIDAmolecular_function
GO:0005262Calcium channel activityTASmolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005886Plasma membraneTAScellular_component
GO:0005887Integral component of plasma membraneTAScellular_component
GO:0006810TransportTASbiological_process
GO:0006811Ion transportIDAbiological_process
GO:0006812Cation transportIBAbiological_process
GO:0006919Activation of cysteine-type endopeptidase activity involved in apoptotic processIEAbiological_process
GO:0007165Signal transductionTASbiological_process
GO:0007320InseminationIEAbiological_process
GO:0007596Blood coagulationTASbiological_process
GO:0008144Drug bindingIEAmolecular_function
GO:0008217Regulation of blood pressureIEAbiological_process
GO:0008270Zinc ion bindingIEAmolecular_function
GO:0016020MembraneIEAcellular_component
GO:0019228Neuronal action potentialIEAbiological_process
GO:0030001Metal ion transportTASbiological_process
GO:0030168Platelet activationIEAbiological_process
GO:0031240External side of cell outer membraneIEAcellular_component
GO:0033198Response to ATPIEAbiological_process
GO:0034220Ion transmembrane transportIBA IDA TASbiological_process
GO:0035249Synaptic transmission, glutamatergicIEAbiological_process
GO:0035587Purinergic receptor signaling pathwayIDAbiological_process
GO:0035590Purinergic nucleotide receptor signaling pathwayIDAbiological_process
GO:0042310VasoconstrictionIEAbiological_process
GO:0043005Neuron projectionIEAcellular_component
GO:0043234Protein complexIEAcellular_component
GO:0043270Positive regulation of ion transportIEAbiological_process
GO:0045121Membrane raftIEAcellular_component
GO:0045211Postsynaptic membraneIEAcellular_component
GO:0046513Ceramide biosynthetic processIEAbiological_process
GO:0051260Protein homooligomerizationIEAbiological_process
GO:0051291Protein heterooligomerizationIEAbiological_process
GO:0051924Regulation of calcium ion transportIEAbiological_process
GO:0055085Transmembrane transportIBA IDA TASbiological_process
GO:0070588Calcium ion transmembrane transportTASbiological_process
GO:0072511Divalent inorganic cation transportTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.48228144450.84773356260.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0087225030
GSE13712_SHEARDown-0.4469544180
GSE13712_STATICUp0.1666171073
GSE19018Down-0.0025909199
GSE19899_A1Down-0.0407656851
GSE19899_A2Down-0.0907834756
PubMed_21979375_A1Up0.0780009191
PubMed_21979375_A2Down-0.2744910353
GSE35957Up0.4033998867
GSE36640Up0.1887022683
GSE54402Up0.0589625959
GSE9593Down-0.1393096103
GSE43922Up0.1094582940
GSE24585Up0.1548746757
GSE37065Down-0.0383753838
GSE28863_A1Up0.0101463519
GSE28863_A2Up0.0155420202
GSE28863_A3Up0.3190383816
GSE28863_A4Up0.1587450032
GSE48662Up0.1571840428

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-335-5pMIMAT0000765MIRT017667MicroarrayFunctional MTI (Weak)18185580
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.