HCSGD entry for OGDH

1. General information

Official gene symbolOGDH
Entrez ID4967
Gene full nameoxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)
Other gene symbolsAKGDH E1k OGDC
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0004591Oxoglutarate dehydrogenase (succinyl-transferring) activityIEA ISSmolecular_function
GO:0005739MitochondrionIDAcellular_component
GO:0005759Mitochondrial matrixTAScellular_component
GO:0006091Generation of precursor metabolites and energyISSbiological_process
GO:0006096GlycolysisIEAbiological_process
GO:0006099Tricarboxylic acid cycleIEA TASbiological_process
GO:00061032-oxoglutarate metabolic processIEAbiological_process
GO:0006104Succinyl-CoA metabolic processIEAbiological_process
GO:0006554Lysine catabolic processTASbiological_process
GO:0006734NADH metabolic processIEAbiological_process
GO:0021695Cerebellar cortex developmentIEAbiological_process
GO:0021756Striatum developmentIEAbiological_process
GO:0021766Hippocampus developmentIEAbiological_process
GO:0021794Thalamus developmentIEAbiological_process
GO:0021860Pyramidal neuron developmentIEAbiological_process
GO:0022028Tangential migration from the subventricular zone to the olfactory bulbIEAbiological_process
GO:0030976Thiamine pyrophosphate bindingIEAmolecular_function
GO:0031072Heat shock protein bindingIEAmolecular_function
GO:0031966Mitochondrial membraneISScellular_component
GO:0034602Oxoglutarate dehydrogenase (NAD+) activityIEAmolecular_function
GO:0034641Cellular nitrogen compound metabolic processTASbiological_process
GO:0044237Cellular metabolic processTASbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
GO:0045252Oxoglutarate dehydrogenase complexIEAcellular_component
GO:0051087Chaperone bindingIEAmolecular_function
GO:0061034Olfactory bulb mitral cell layer developmentIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.07478963190.76571460050.57978446601.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0030261083
GSE13712_SHEARUp0.0676589252
GSE13712_STATICUp0.1765306059
GSE19018Up0.0936395230
GSE19899_A1Down-0.0012302493
GSE19899_A2Up0.1654403681
PubMed_21979375_A1Up0.0023554639
PubMed_21979375_A2Down-0.1035637345
GSE35957Up0.4565369278
GSE36640Up0.1596079094
GSE54402Up0.0182683343
GSE9593Up0.0302012593
GSE43922Up0.1250470155
GSE24585Up0.8745488396
GSE37065Up0.0651478278
GSE28863_A1Up0.0500992758
GSE28863_A2Up0.8687442058
GSE28863_A3Down-0.5792612899
GSE28863_A4Down-0.0982687230
GSE48662Down-0.0849189965

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

NADHDB00157 NUTR00041 | DB01907 | EXPT02287 | DB03527

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-335-5pMIMAT0000765MIRT018112MicroarrayFunctional MTI (Weak)18185580
hsa-miR-30a-5pMIMAT0000087MIRT028586ProteomicsFunctional MTI (Weak)18668040
hsa-miR-16-5pMIMAT0000069MIRT031751ProteomicsFunctional MTI (Weak)18668040
hsa-miR-361-5pMIMAT0000703MIRT044084CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.