HCSGD entry for OGDH

1. General information

Official gene symbolOGDH
Entrez ID4967
Gene full nameoxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)
Other gene symbolsAKGDH E1k OGDC
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0004591Oxoglutarate dehydrogenase (succinyl-transferring) activityIEA ISSmolecular_function
GO:0005739MitochondrionIDAcellular_component
GO:0005759Mitochondrial matrixTAScellular_component
GO:0006091Generation of precursor metabolites and energyISSbiological_process
GO:0006096GlycolysisIEAbiological_process
GO:0006099Tricarboxylic acid cycleIEA TASbiological_process
GO:00061032-oxoglutarate metabolic processIEAbiological_process
GO:0006104Succinyl-CoA metabolic processIEAbiological_process
GO:0006554Lysine catabolic processTASbiological_process
GO:0006734NADH metabolic processIEAbiological_process
GO:0021695Cerebellar cortex developmentIEAbiological_process
GO:0021756Striatum developmentIEAbiological_process
GO:0021766Hippocampus developmentIEAbiological_process
GO:0021794Thalamus developmentIEAbiological_process
GO:0021860Pyramidal neuron developmentIEAbiological_process
GO:0022028Tangential migration from the subventricular zone to the olfactory bulbIEAbiological_process
GO:0030976Thiamine pyrophosphate bindingIEAmolecular_function
GO:0031072Heat shock protein bindingIEAmolecular_function
GO:0031966Mitochondrial membraneISScellular_component
GO:0034602Oxoglutarate dehydrogenase (NAD+) activityIEAmolecular_function
GO:0034641Cellular nitrogen compound metabolic processTASbiological_process
GO:0044237Cellular metabolic processTASbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
GO:0045252Oxoglutarate dehydrogenase complexIEAcellular_component
GO:0051087Chaperone bindingIEAmolecular_function
GO:0061034Olfactory bulb mitral cell layer developmentIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.07478963190.76571460050.57978446601.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0030261083
GSE13712_SHEARUp0.0676589252
GSE13712_STATICUp0.1765306059
GSE19018Up0.0936395230
GSE19899_A1Down-0.0012302493
GSE19899_A2Up0.1654403681
PubMed_21979375_A1Up0.0023554639
PubMed_21979375_A2Down-0.1035637345
GSE35957Up0.4565369278
GSE36640Up0.1596079094
GSE54402Up0.0182683343
GSE9593Up0.0302012593
GSE43922Up0.1250470155
GSE24585Up0.8745488396
GSE37065Up0.0651478278
GSE28863_A1Up0.0500992758
GSE28863_A2Up0.8687442058
GSE28863_A3Down-0.5792612899
GSE28863_A4Down-0.0982687230
GSE48662Down-0.0849189965

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

NADHDB00157 NUTR00041 | DB01907 | EXPT02287 | DB03527

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-335-5pMIMAT0000765MIRT018112MicroarrayFunctional MTI (Weak)18185580
hsa-miR-30a-5pMIMAT0000087MIRT028586ProteomicsFunctional MTI (Weak)18668040
hsa-miR-16-5pMIMAT0000069MIRT031751ProteomicsFunctional MTI (Weak)18668040
hsa-miR-361-5pMIMAT0000703MIRT044084CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.