HCSGD entry for OCRL

1. General information

Official gene symbolOCRL
Entrez ID4952
Gene full nameoculocerebrorenal syndrome of Lowe
Other gene symbolsINPP5F LOCR NPHL2 OCRL-1 OCRL1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001701In utero embryonic developmentIEAbiological_process
GO:0001750Photoreceptor outer segmentIDAcellular_component
GO:0004439Phosphatidylinositol-4,5-bisphosphate 5-phosphatase activityIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005769Early endosomeIDAcellular_component
GO:0005795Golgi stackTAScellular_component
GO:0005798Golgi-associated vesicleTAScellular_component
GO:0005802Trans-Golgi networkIDAcellular_component
GO:0005829CytosolTAScellular_component
GO:0005886Plasma membraneIDAcellular_component
GO:0005905Coated pitIEAcellular_component
GO:0006629Lipid metabolic processNASbiological_process
GO:0006644Phospholipid metabolic processTASbiological_process
GO:0006661Phosphatidylinositol biosynthetic processTASbiological_process
GO:0007264Small GTPase mediated signal transductionTASbiological_process
GO:0030136Clathrin-coated vesicleIDAcellular_component
GO:0030670Phagocytic vesicle membraneIEAcellular_component
GO:0030675Rac GTPase activator activityIDAmolecular_function
GO:0031901Early endosome membraneIEAcellular_component
GO:0032314Regulation of Rac GTPase activityIDAbiological_process
GO:0032320Positive regulation of Ras GTPase activityIDAbiological_process
GO:0032321Positive regulation of Rho GTPase activityIDAbiological_process
GO:0032855Positive regulation of Rac GTPase activityIDAbiological_process
GO:0042384Cilium assemblyIMPbiological_process
GO:0043085Positive regulation of catalytic activityIDAbiological_process
GO:0043547Positive regulation of GTPase activityIDAbiological_process
GO:0043647Inositol phosphate metabolic processTASbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
GO:0046856Phosphatidylinositol dephosphorylationIEAbiological_process
GO:0048365Rac GTPase bindingIPImolecular_function
GO:0051056Regulation of small GTPase mediated signal transductionTASbiological_process
GO:0052745Inositol phosphate phosphatase activityNASmolecular_function
Entries Per Page
Displaying Page of

4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.42592016260.27273425780.99999024730.9987342329

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0744328027
GSE13712_SHEARDown-0.1500940135
GSE13712_STATICUp0.2187347307
GSE19018Down-0.1093252519
GSE19899_A1Down-0.1496862229
GSE19899_A2Down-0.3209518561
PubMed_21979375_A1Down-0.3200492782
PubMed_21979375_A2Down-0.2144318869
GSE35957Up0.5651030648
GSE36640Up0.8576947987
GSE54402Down-0.2001164902
GSE9593Up0.4878500948
GSE43922Down-0.0223919327
GSE24585Down-0.2998394047
GSE37065Down-0.0557124295
GSE28863_A1Up0.2630729548
GSE28863_A2Up0.3852625874
GSE28863_A3Down-0.5000180706
GSE28863_A4Up0.1097960534
GSE48662Down-0.0077611132

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-484MIMAT0002174MIRT042349CLASHFunctional MTI (Weak)23622248
hsa-miR-378a-3pMIMAT0000732MIRT043931CLASHFunctional MTI (Weak)23622248
hsa-miR-320aMIMAT0000510MIRT044664CLASHFunctional MTI (Weak)23622248
hsa-miR-10a-5pMIMAT0000253MIRT047730CLASHFunctional MTI (Weak)23622248
Entries Per Page
Displaying Page of
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.