HCSGD entry for OCRL

1. General information

Official gene symbolOCRL
Entrez ID4952
Gene full nameoculocerebrorenal syndrome of Lowe
Other gene symbolsINPP5F LOCR NPHL2 OCRL-1 OCRL1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001701In utero embryonic developmentIEAbiological_process
GO:0001750Photoreceptor outer segmentIDAcellular_component
GO:0004439Phosphatidylinositol-4,5-bisphosphate 5-phosphatase activityIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005769Early endosomeIDAcellular_component
GO:0005795Golgi stackTAScellular_component
GO:0005798Golgi-associated vesicleTAScellular_component
GO:0005802Trans-Golgi networkIDAcellular_component
GO:0005829CytosolTAScellular_component
GO:0005886Plasma membraneIDAcellular_component
GO:0005905Coated pitIEAcellular_component
GO:0006629Lipid metabolic processNASbiological_process
GO:0006644Phospholipid metabolic processTASbiological_process
GO:0006661Phosphatidylinositol biosynthetic processTASbiological_process
GO:0007264Small GTPase mediated signal transductionTASbiological_process
GO:0030136Clathrin-coated vesicleIDAcellular_component
GO:0030670Phagocytic vesicle membraneIEAcellular_component
GO:0030675Rac GTPase activator activityIDAmolecular_function
GO:0031901Early endosome membraneIEAcellular_component
GO:0032314Regulation of Rac GTPase activityIDAbiological_process
GO:0032320Positive regulation of Ras GTPase activityIDAbiological_process
GO:0032321Positive regulation of Rho GTPase activityIDAbiological_process
GO:0032855Positive regulation of Rac GTPase activityIDAbiological_process
GO:0042384Cilium assemblyIMPbiological_process
GO:0043085Positive regulation of catalytic activityIDAbiological_process
GO:0043547Positive regulation of GTPase activityIDAbiological_process
GO:0043647Inositol phosphate metabolic processTASbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
GO:0046856Phosphatidylinositol dephosphorylationIEAbiological_process
GO:0048365Rac GTPase bindingIPImolecular_function
GO:0051056Regulation of small GTPase mediated signal transductionTASbiological_process
GO:0052745Inositol phosphate phosphatase activityNASmolecular_function
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.42592016260.27273425780.99999024730.9987342329

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0744328027
GSE13712_SHEARDown-0.1500940135
GSE13712_STATICUp0.2187347307
GSE19018Down-0.1093252519
GSE19899_A1Down-0.1496862229
GSE19899_A2Down-0.3209518561
PubMed_21979375_A1Down-0.3200492782
PubMed_21979375_A2Down-0.2144318869
GSE35957Up0.5651030648
GSE36640Up0.8576947987
GSE54402Down-0.2001164902
GSE9593Up0.4878500948
GSE43922Down-0.0223919327
GSE24585Down-0.2998394047
GSE37065Down-0.0557124295
GSE28863_A1Up0.2630729548
GSE28863_A2Up0.3852625874
GSE28863_A3Down-0.5000180706
GSE28863_A4Up0.1097960534
GSE48662Down-0.0077611132

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-484MIMAT0002174MIRT042349CLASHFunctional MTI (Weak)23622248
hsa-miR-378a-3pMIMAT0000732MIRT043931CLASHFunctional MTI (Weak)23622248
hsa-miR-320aMIMAT0000510MIRT044664CLASHFunctional MTI (Weak)23622248
hsa-miR-10a-5pMIMAT0000253MIRT047730CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.