HCSGD entry for NR4A2

1. General information

Official gene symbolNR4A2
Entrez ID4929
Gene full namenuclear receptor subfamily 4, group A, member 2
Other gene symbolsHZF-3 NOT NURR1 RNR1 TINUR
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001666Response to hypoxiaIEAbiological_process
GO:0001764Neuron migrationIEAbiological_process
GO:0001975Response to amphetamineIEAbiological_process
GO:0003707Steroid hormone receptor activityIEAmolecular_function
GO:0004879Ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activityIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDA IEAcellular_component
GO:0005654NucleoplasmTAScellular_component
GO:0005737CytoplasmIEAcellular_component
GO:0006351Transcription, DNA-templatedIDAbiological_process
GO:0006367Transcription initiation from RNA polymerase II promoterTASbiological_process
GO:0007165Signal transductionNASbiological_process
GO:0008270Zinc ion bindingIEAmolecular_function
GO:0008344Adult locomotory behaviorIEAbiological_process
GO:0009791Post-embryonic developmentIEAbiological_process
GO:0010035Response to inorganic substanceIEAbiological_process
GO:0010467Gene expressionTASbiological_process
GO:0016265DeathIEAbiological_process
GO:0017085Response to insecticideIEAbiological_process
GO:0021952Central nervous system projection neuron axonogenesisIEAbiological_process
GO:0021986Habenula developmentIEAbiological_process
GO:0030522Intracellular receptor signaling pathwayTASbiological_process
GO:0031668Cellular response to extracellular stimulusIDAbiological_process
GO:0034599Cellular response to oxidative stressIEAbiological_process
GO:0042053Regulation of dopamine metabolic processIEAbiological_process
GO:0042416Dopamine biosynthetic processIEAbiological_process
GO:0042551Neuron maturationIEAbiological_process
GO:0043085Positive regulation of catalytic activityIEAbiological_process
GO:0043524Negative regulation of neuron apoptotic processIEAbiological_process
GO:0043565Sequence-specific DNA bindingIEAmolecular_function
GO:0043576Regulation of respiratory gaseous exchangeIEAbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIEAbiological_process
GO:0046982Protein heterodimerization activityIEAmolecular_function
GO:0051866General adaptation syndromeIEAbiological_process
GO:0071542Dopaminergic neuron differentiationIEA ISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.04556377420.05790529240.47402533600.4528001188

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-3.0217058368
GSE13712_SHEARUp0.2785566293
GSE13712_STATICUp0.0418392906
GSE19018Down-0.3767045397
GSE19899_A1Up0.5332658047
GSE19899_A2Up0.1771441236
PubMed_21979375_A1Up2.7030462031
PubMed_21979375_A2Up0.5440719895
GSE35957Down-0.9562413929
GSE36640Down-0.1041042897
GSE54402Down-0.3122078659
GSE9593Up0.1520682985
GSE43922Up0.4038834253
GSE24585Down-0.4660849434
GSE37065Up1.3745213692
GSE28863_A1Up0.0755520990
GSE28863_A2Down-0.1272007951
GSE28863_A3Down-0.0920917910
GSE28863_A4Down-0.0808616210
GSE48662Up0.1481091508

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-217MIMAT0000274MIRT003535Luciferase reporter assay//MicroarrayFunctional MTI19885849
hsa-miR-19a-3pMIMAT0000073MIRT003536Luciferase reporter assay//MicroarrayFunctional MTI19885849
hsa-miR-302d-3pMIMAT0000718MIRT003537Luciferase reporter assay//MicroarrayFunctional MTI19885849
hsa-miR-372-3pMIMAT0000724MIRT003538Luciferase reporter assay//MicroarrayFunctional MTI19885849
hsa-miR-335-5pMIMAT0000765MIRT018465MicroarrayFunctional MTI (Weak)18185580
hsa-miR-133a-3pMIMAT0000427MIRT045837CLASHFunctional MTI (Weak)23622248
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    • mirRecord

MicroRNA name

mirBase ID

Target site number

MiRNA mature ID

Test method inter

MiRNA regulation site

Reporter target site

Pubmed ID

hsa-miR-302d-3pMIMAT0000718NAhsa-miR-302d19885849
hsa-miR-19a-3pMIMAT0000073NAhsa-miR-19a19885849
hsa-miR-217MIMAT0000274NAhsa-miR-21719885849
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6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.