HCSGD entry for NR4A2
1. General information
| Official gene symbol | NR4A2 |
|---|---|
| Entrez ID | 4929 |
| Gene full name | nuclear receptor subfamily 4, group A, member 2 |
| Other gene symbols | HZF-3 NOT NURR1 RNR1 TINUR |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001666 | Response to hypoxia | IEA | biological_process |
| GO:0001764 | Neuron migration | IEA | biological_process |
| GO:0001975 | Response to amphetamine | IEA | biological_process |
| GO:0003707 | Steroid hormone receptor activity | IEA | molecular_function |
| GO:0004879 | Ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA IEA | cellular_component |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0005737 | Cytoplasm | IEA | cellular_component |
| GO:0006351 | Transcription, DNA-templated | IDA | biological_process |
| GO:0006367 | Transcription initiation from RNA polymerase II promoter | TAS | biological_process |
| GO:0007165 | Signal transduction | NAS | biological_process |
| GO:0008270 | Zinc ion binding | IEA | molecular_function |
| GO:0008344 | Adult locomotory behavior | IEA | biological_process |
| GO:0009791 | Post-embryonic development | IEA | biological_process |
| GO:0010035 | Response to inorganic substance | IEA | biological_process |
| GO:0010467 | Gene expression | TAS | biological_process |
| GO:0016265 | Death | IEA | biological_process |
| GO:0017085 | Response to insecticide | IEA | biological_process |
| GO:0021952 | Central nervous system projection neuron axonogenesis | IEA | biological_process |
| GO:0021986 | Habenula development | IEA | biological_process |
| GO:0030522 | Intracellular receptor signaling pathway | TAS | biological_process |
| GO:0031668 | Cellular response to extracellular stimulus | IDA | biological_process |
| GO:0034599 | Cellular response to oxidative stress | IEA | biological_process |
| GO:0042053 | Regulation of dopamine metabolic process | IEA | biological_process |
| GO:0042416 | Dopamine biosynthetic process | IEA | biological_process |
| GO:0042551 | Neuron maturation | IEA | biological_process |
| GO:0043085 | Positive regulation of catalytic activity | IEA | biological_process |
| GO:0043524 | Negative regulation of neuron apoptotic process | IEA | biological_process |
| GO:0043565 | Sequence-specific DNA binding | IEA | molecular_function |
| GO:0043576 | Regulation of respiratory gaseous exchange | IEA | biological_process |
| GO:0045944 | Positive regulation of transcription from RNA polymerase II promoter | IEA | biological_process |
| GO:0046982 | Protein heterodimerization activity | IEA | molecular_function |
| GO:0051866 | General adaptation syndrome | IEA | biological_process |
| GO:0071542 | Dopaminergic neuron differentiation | IEA ISS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0455637742 | 0.0579052924 | 0.4740253360 | 0.4528001188 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -3.0217058368 |
| GSE13712_SHEAR | Up | 0.2785566293 |
| GSE13712_STATIC | Up | 0.0418392906 |
| GSE19018 | Down | -0.3767045397 |
| GSE19899_A1 | Up | 0.5332658047 |
| GSE19899_A2 | Up | 0.1771441236 |
| PubMed_21979375_A1 | Up | 2.7030462031 |
| PubMed_21979375_A2 | Up | 0.5440719895 |
| GSE35957 | Down | -0.9562413929 |
| GSE36640 | Down | -0.1041042897 |
| GSE54402 | Down | -0.3122078659 |
| GSE9593 | Up | 0.1520682985 |
| GSE43922 | Up | 0.4038834253 |
| GSE24585 | Down | -0.4660849434 |
| GSE37065 | Up | 1.3745213692 |
| GSE28863_A1 | Up | 0.0755520990 |
| GSE28863_A2 | Down | -0.1272007951 |
| GSE28863_A3 | Down | -0.0920917910 |
| GSE28863_A4 | Down | -0.0808616210 |
| GSE48662 | Up | 0.1481091508 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-217 | MIMAT0000274 | MIRT003535 | Luciferase reporter assay//Microarray | Functional MTI | 19885849 |
| hsa-miR-19a-3p | MIMAT0000073 | MIRT003536 | Luciferase reporter assay//Microarray | Functional MTI | 19885849 |
| hsa-miR-302d-3p | MIMAT0000718 | MIRT003537 | Luciferase reporter assay//Microarray | Functional MTI | 19885849 |
| hsa-miR-372-3p | MIMAT0000724 | MIRT003538 | Luciferase reporter assay//Microarray | Functional MTI | 19885849 |
| hsa-miR-335-5p | MIMAT0000765 | MIRT018465 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-133a-3p | MIMAT0000427 | MIRT045837 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
MicroRNA name | mirBase ID | Target site number | MiRNA mature ID | Test method inter | MiRNA regulation site | Reporter target site | Pubmed ID |
|---|---|---|---|---|---|---|---|
| hsa-miR-302d-3p | MIMAT0000718 | NA | hsa-miR-302d | 19885849 | |||
| hsa-miR-19a-3p | MIMAT0000073 | NA | hsa-miR-19a | 19885849 | |||
| hsa-miR-217 | MIMAT0000274 | NA | hsa-miR-217 | 19885849 |
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6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
