HCSGD entry for DDR2

1. General information

Official gene symbolDDR2
Entrez ID4921
Gene full namediscoidin domain receptor tyrosine kinase 2
Other gene symbolsMIG20a NTRKR3 TKT TYRO10
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001503OssificationIEAbiological_process
GO:0003416Endochondral bone growthIEA ISSbiological_process
GO:0004714Transmembrane receptor protein tyrosine kinase activityIDAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005518Collagen bindingIDA IEAmolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005886Plasma membraneTAScellular_component
GO:0005887Integral component of plasma membraneTAScellular_component
GO:0007155Cell adhesionIEAbiological_process
GO:0007165Signal transductionTASbiological_process
GO:0010715Regulation of extracellular matrix disassemblyTASbiological_process
GO:0010763Positive regulation of fibroblast migrationIEA ISS TASbiological_process
GO:0016324Apical plasma membraneIEAcellular_component
GO:0018108Peptidyl-tyrosine phosphorylationIDAbiological_process
GO:0030198Extracellular matrix organizationTASbiological_process
GO:0030199Collagen fibril organizationIEA ISSbiological_process
GO:0030500Regulation of bone mineralizationIMPbiological_process
GO:0031214Biomineral tissue developmentIEA ISSbiological_process
GO:0035988Chondrocyte proliferationIEA ISS TASbiological_process
GO:0038062Protein tyrosine kinase collagen receptor activityIDA IEAmolecular_function
GO:0038063Collagen-activated tyrosine kinase receptor signaling pathwayIDAbiological_process
GO:0045669Positive regulation of osteoblast differentiationIMPbiological_process
GO:0045860Positive regulation of protein kinase activityIMPbiological_process
GO:0046777Protein autophosphorylationIDAbiological_process
GO:0048146Positive regulation of fibroblast proliferationIEA ISSbiological_process
GO:0051091Positive regulation of sequence-specific DNA binding transcription factor activityIMPbiological_process
GO:0090091Positive regulation of extracellular matrix disassemblyIEA ISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.81257156260.00329865130.99999024730.1161490642

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.1448780777
GSE13712_SHEARDown-0.8659758168
GSE13712_STATICDown-0.6517876357
GSE19018Up0.0592118630
GSE19899_A1Down-1.0947759907
GSE19899_A2Down-1.3272911573
PubMed_21979375_A1Down-3.0607653002
PubMed_21979375_A2Down-1.9043653910
GSE35957Up0.2615077894
GSE36640Up0.2603151955
GSE54402Down-0.6666056071
GSE9593Up1.0706561153
GSE43922Down-1.0708997921
GSE24585Down-0.3786193968
GSE37065Down-0.2996210370
GSE28863_A1Up0.1049262316
GSE28863_A2Up0.3615941936
GSE28863_A3Down-0.3696537009
GSE28863_A4Down-0.1906119967
GSE48662Up0.6380701970

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

RegorafenibDB08896 -

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-21-5pMIMAT0000076MIRT030671MicroarrayFunctional MTI (Weak)18591254
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.