HCSGD entry for DDR2

1. General information

Official gene symbolDDR2
Entrez ID4921
Gene full namediscoidin domain receptor tyrosine kinase 2
Other gene symbolsMIG20a NTRKR3 TKT TYRO10
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001503OssificationIEAbiological_process
GO:0003416Endochondral bone growthIEA ISSbiological_process
GO:0004714Transmembrane receptor protein tyrosine kinase activityIDAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005518Collagen bindingIDA IEAmolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005886Plasma membraneTAScellular_component
GO:0005887Integral component of plasma membraneTAScellular_component
GO:0007155Cell adhesionIEAbiological_process
GO:0007165Signal transductionTASbiological_process
GO:0010715Regulation of extracellular matrix disassemblyTASbiological_process
GO:0010763Positive regulation of fibroblast migrationIEA ISS TASbiological_process
GO:0016324Apical plasma membraneIEAcellular_component
GO:0018108Peptidyl-tyrosine phosphorylationIDAbiological_process
GO:0030198Extracellular matrix organizationTASbiological_process
GO:0030199Collagen fibril organizationIEA ISSbiological_process
GO:0030500Regulation of bone mineralizationIMPbiological_process
GO:0031214Biomineral tissue developmentIEA ISSbiological_process
GO:0035988Chondrocyte proliferationIEA ISS TASbiological_process
GO:0038062Protein tyrosine kinase collagen receptor activityIDA IEAmolecular_function
GO:0038063Collagen-activated tyrosine kinase receptor signaling pathwayIDAbiological_process
GO:0045669Positive regulation of osteoblast differentiationIMPbiological_process
GO:0045860Positive regulation of protein kinase activityIMPbiological_process
GO:0046777Protein autophosphorylationIDAbiological_process
GO:0048146Positive regulation of fibroblast proliferationIEA ISSbiological_process
GO:0051091Positive regulation of sequence-specific DNA binding transcription factor activityIMPbiological_process
GO:0090091Positive regulation of extracellular matrix disassemblyIEA ISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.81257156260.00329865130.99999024730.1161490642

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.1448780777
GSE13712_SHEARDown-0.8659758168
GSE13712_STATICDown-0.6517876357
GSE19018Up0.0592118630
GSE19899_A1Down-1.0947759907
GSE19899_A2Down-1.3272911573
PubMed_21979375_A1Down-3.0607653002
PubMed_21979375_A2Down-1.9043653910
GSE35957Up0.2615077894
GSE36640Up0.2603151955
GSE54402Down-0.6666056071
GSE9593Up1.0706561153
GSE43922Down-1.0708997921
GSE24585Down-0.3786193968
GSE37065Down-0.2996210370
GSE28863_A1Up0.1049262316
GSE28863_A2Up0.3615941936
GSE28863_A3Down-0.3696537009
GSE28863_A4Down-0.1906119967
GSE48662Up0.6380701970

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

RegorafenibDB08896 -

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-21-5pMIMAT0000076MIRT030671MicroarrayFunctional MTI (Weak)18591254
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.