HCSGD entry for NPPB

1. General information

Official gene symbolNPPB
Entrez ID4879
Gene full namenatriuretic peptide B
Other gene symbolsBNP
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0005102Receptor bindingIDA IPImolecular_function
GO:0005179Hormone activityNASmolecular_function
GO:0005576Extracellular regionTAScellular_component
GO:0005615Extracellular spaceNAScellular_component
GO:0006182CGMP biosynthetic processIDAbiological_process
GO:0007166Cell surface receptor signaling pathwayNASbiological_process
GO:0007168Receptor guanylyl cyclase signaling pathwayIDAbiological_process
GO:0007589Body fluid secretionTASbiological_process
GO:0008217Regulation of blood pressureNASbiological_process
GO:0008613Diuretic hormone activityTASmolecular_function
GO:0016525Negative regulation of angiogenesisTASbiological_process
GO:0030308Negative regulation of cell growthNASbiological_process
GO:0035810Positive regulation of urine volumeTASbiological_process
GO:0035815Positive regulation of renal sodium excretionTASbiological_process
GO:0042312Regulation of vasodilationNASbiological_process
GO:0043114Regulation of vascular permeabilityTASbiological_process
GO:0043234Protein complexIDAcellular_component
GO:0050880Regulation of blood vessel sizeIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.26599369700.52751487790.96172314561.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-1.6304531770
GSE13712_SHEARUp0.1368365917
GSE13712_STATICUp0.1236143995
GSE19018Up0.4007296796
GSE19899_A1Up0.1334717492
GSE19899_A2Up0.1503545499
PubMed_21979375_A1Down-0.2804643823
PubMed_21979375_A2Up0.0484419075
GSE35957Up0.1605455601
GSE36640Up0.0825076886
GSE54402Down-0.1054669364
GSE9593Up0.0236781005
GSE43922Up0.2318335625
GSE24585Up0.0411172529
GSE37065Up0.0156385497
GSE28863_A1Up0.0144143326
GSE28863_A2Up0.1571543994
GSE28863_A3Up0.2610908720
GSE28863_A4Down-0.0500814636
GSE48662Down-0.0362521539

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

CarvedilolDB01136 APRD00091
OxymetholoneDB06412 -

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-375MIMAT0000728MIRT019803MicroarrayFunctional MTI (Weak)20215506
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

20622962Downregulated genes included cyclin D2, keratin 8, insulin-like growth factor 2 (IGF2), natriuretic peptide precursor B (NPPB) and cellular retinoic acid binding protein 2 (CRABP2)
20622962Interestingly, the expression of NPPB was dramatically downregulated along the time course; it was almost completely shut-down by the 10(th) passage
20622962CONCLUSION: Taken together, although a function for NPPB and FOLR3 in stem cell senescence has not been reported, our results strongly suggest that NPPB and/or FOLR3 play a significant role in the regulation of stem cell senescence
19826180OR-1896 also ameliorated salt-induced increase in cardiac ANP mRNA expression and plasma BNP level
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