HCSGD entry for NPPB

1. General information

Official gene symbolNPPB
Entrez ID4879
Gene full namenatriuretic peptide B
Other gene symbolsBNP
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0005102Receptor bindingIDA IPImolecular_function
GO:0005179Hormone activityNASmolecular_function
GO:0005576Extracellular regionTAScellular_component
GO:0005615Extracellular spaceNAScellular_component
GO:0006182CGMP biosynthetic processIDAbiological_process
GO:0007166Cell surface receptor signaling pathwayNASbiological_process
GO:0007168Receptor guanylyl cyclase signaling pathwayIDAbiological_process
GO:0007589Body fluid secretionTASbiological_process
GO:0008217Regulation of blood pressureNASbiological_process
GO:0008613Diuretic hormone activityTASmolecular_function
GO:0016525Negative regulation of angiogenesisTASbiological_process
GO:0030308Negative regulation of cell growthNASbiological_process
GO:0035810Positive regulation of urine volumeTASbiological_process
GO:0035815Positive regulation of renal sodium excretionTASbiological_process
GO:0042312Regulation of vasodilationNASbiological_process
GO:0043114Regulation of vascular permeabilityTASbiological_process
GO:0043234Protein complexIDAcellular_component
GO:0050880Regulation of blood vessel sizeIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.26599369700.52751487790.96172314561.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-1.6304531770
GSE13712_SHEARUp0.1368365917
GSE13712_STATICUp0.1236143995
GSE19018Up0.4007296796
GSE19899_A1Up0.1334717492
GSE19899_A2Up0.1503545499
PubMed_21979375_A1Down-0.2804643823
PubMed_21979375_A2Up0.0484419075
GSE35957Up0.1605455601
GSE36640Up0.0825076886
GSE54402Down-0.1054669364
GSE9593Up0.0236781005
GSE43922Up0.2318335625
GSE24585Up0.0411172529
GSE37065Up0.0156385497
GSE28863_A1Up0.0144143326
GSE28863_A2Up0.1571543994
GSE28863_A3Up0.2610908720
GSE28863_A4Down-0.0500814636
GSE48662Down-0.0362521539

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

CarvedilolDB01136 APRD00091
OxymetholoneDB06412 -

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-375MIMAT0000728MIRT019803MicroarrayFunctional MTI (Weak)20215506
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

20622962Downregulated genes included cyclin D2, keratin 8, insulin-like growth factor 2 (IGF2), natriuretic peptide precursor B (NPPB) and cellular retinoic acid binding protein 2 (CRABP2)
20622962Interestingly, the expression of NPPB was dramatically downregulated along the time course; it was almost completely shut-down by the 10(th) passage
20622962CONCLUSION: Taken together, although a function for NPPB and FOLR3 in stem cell senescence has not been reported, our results strongly suggest that NPPB and/or FOLR3 play a significant role in the regulation of stem cell senescence
19826180OR-1896 also ameliorated salt-induced increase in cardiac ANP mRNA expression and plasma BNP level
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