HCSGD entry for NPPA

1. General information

Official gene symbolNPPA
Entrez ID4878
Gene full namenatriuretic peptide A
Other gene symbolsANF ANP ATFB6 CDD-ANF PND
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001666Response to hypoxiaIEAbiological_process
GO:0003085Negative regulation of systemic arterial blood pressureIEAbiological_process
GO:0005102Receptor bindingIDA IPImolecular_function
GO:0005179Hormone activityIEAmolecular_function
GO:0005576Extracellular regionNAS TAScellular_component
GO:0005615Extracellular spaceIEAcellular_component
GO:0005634NucleusIEAcellular_component
GO:0006182CGMP biosynthetic processIDA IEAbiological_process
GO:0006367Transcription initiation from RNA polymerase II promoterTASbiological_process
GO:0007168Receptor guanylyl cyclase signaling pathwayIDAbiological_process
GO:0007565Female pregnancyIEA ISSbiological_process
GO:0008217Regulation of blood pressureIDAbiological_process
GO:0010467Gene expressionTASbiological_process
GO:0014898Cardiac muscle hypertrophy in response to stressIEAbiological_process
GO:0030308Negative regulation of cell growthIEAbiological_process
GO:0032868Response to insulinIEAbiological_process
GO:0042629Mast cell granuleIEAcellular_component
GO:0048471Perinuclear region of cytoplasmIEAcellular_component
GO:0050880Regulation of blood vessel sizeIEAbiological_process
GO:0051428Peptide hormone receptor bindingIEAmolecular_function
GO:0071260Cellular response to mechanical stimulusIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.65116627410.62166470500.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0702303636
GSE13712_SHEARDown-0.0463046795
GSE13712_STATICDown-0.0448420855
GSE19018Up0.0198616196
GSE19899_A1Down-0.0041164400
GSE19899_A2Up0.6307107749
PubMed_21979375_A1Down-0.1208221429
PubMed_21979375_A2Down-0.0055015766
GSE35957Up0.0318085641
GSE36640Up0.2393868932
GSE54402Down-0.1744183282
GSE9593Up0.3330878655
GSE43922Up0.0101626355
GSE24585Up0.0466382037
GSE37065Down-0.0542184243
GSE28863_A1Down-0.3528365775
GSE28863_A2Down-0.0475473449
GSE28863_A3Up0.0163630117
GSE28863_A4Up0.0072464536
GSE48662Up0.0650876968

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase
No target information from mirTarBase
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

19826180OR-1896 also ameliorated salt-induced increase in cardiac ANP mRNA expression and plasma BNP level
19730126Postinfarct cardiac remodeling was associated with increased atrial natriuretic peptide, interleukin-6 and connective tissue growth factor mRNA expressions, as well as three-fold increased cardiomyocyte senescence, measured as cardiac p16 mRNA expression
19730126Levosimendan also ameliorated MI-induced atrial natriuretic peptide, IL-6, and connective tissue growth factor overexpression as well as MI-induced disturbances in calcium-handling proteins (SERCA2, Na-Ca exchanger) without changes in diabetic status or systemic blood pressure
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