HCSGD entry for NPPA

1. General information

Official gene symbolNPPA
Entrez ID4878
Gene full namenatriuretic peptide A
Other gene symbolsANF ANP ATFB6 CDD-ANF PND
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001666Response to hypoxiaIEAbiological_process
GO:0003085Negative regulation of systemic arterial blood pressureIEAbiological_process
GO:0005102Receptor bindingIDA IPImolecular_function
GO:0005179Hormone activityIEAmolecular_function
GO:0005576Extracellular regionNAS TAScellular_component
GO:0005615Extracellular spaceIEAcellular_component
GO:0005634NucleusIEAcellular_component
GO:0006182CGMP biosynthetic processIDA IEAbiological_process
GO:0006367Transcription initiation from RNA polymerase II promoterTASbiological_process
GO:0007168Receptor guanylyl cyclase signaling pathwayIDAbiological_process
GO:0007565Female pregnancyIEA ISSbiological_process
GO:0008217Regulation of blood pressureIDAbiological_process
GO:0010467Gene expressionTASbiological_process
GO:0014898Cardiac muscle hypertrophy in response to stressIEAbiological_process
GO:0030308Negative regulation of cell growthIEAbiological_process
GO:0032868Response to insulinIEAbiological_process
GO:0042629Mast cell granuleIEAcellular_component
GO:0048471Perinuclear region of cytoplasmIEAcellular_component
GO:0050880Regulation of blood vessel sizeIEAbiological_process
GO:0051428Peptide hormone receptor bindingIEAmolecular_function
GO:0071260Cellular response to mechanical stimulusIEAbiological_process
Entries Per Page
Displaying Page of

4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.65116627410.62166470500.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0702303636
GSE13712_SHEARDown-0.0463046795
GSE13712_STATICDown-0.0448420855
GSE19018Up0.0198616196
GSE19899_A1Down-0.0041164400
GSE19899_A2Up0.6307107749
PubMed_21979375_A1Down-0.1208221429
PubMed_21979375_A2Down-0.0055015766
GSE35957Up0.0318085641
GSE36640Up0.2393868932
GSE54402Down-0.1744183282
GSE9593Up0.3330878655
GSE43922Up0.0101626355
GSE24585Up0.0466382037
GSE37065Down-0.0542184243
GSE28863_A1Down-0.3528365775
GSE28863_A2Down-0.0475473449
GSE28863_A3Up0.0163630117
GSE28863_A4Up0.0072464536
GSE48662Up0.0650876968

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase
No target information from mirTarBase
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

19826180OR-1896 also ameliorated salt-induced increase in cardiac ANP mRNA expression and plasma BNP level
19730126Postinfarct cardiac remodeling was associated with increased atrial natriuretic peptide, interleukin-6 and connective tissue growth factor mRNA expressions, as well as three-fold increased cardiomyocyte senescence, measured as cardiac p16 mRNA expression
19730126Levosimendan also ameliorated MI-induced atrial natriuretic peptide, IL-6, and connective tissue growth factor overexpression as well as MI-induced disturbances in calcium-handling proteins (SERCA2, Na-Ca exchanger) without changes in diabetic status or systemic blood pressure
Entries Per Page
Displaying Page of