HCSGD entry for ATP2A1

1. General information

Official gene symbolATP2A1
Entrez ID487
Gene full nameATPase, Ca++ transporting, cardiac muscle, fast twitch 1
Other gene symbolsATP2A SERCA1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000166Nucleotide bindingIEAmolecular_function
GO:0005388Calcium-transporting ATPase activityIDA IEAmolecular_function
GO:0005509Calcium ion bindingIMP ISSmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIEA ISSmolecular_function
GO:0005789Endoplasmic reticulum membraneIDA TAScellular_component
GO:0005793Endoplasmic reticulum-Golgi intermediate compartmentISScellular_component
GO:0006200ATP catabolic processIDA ISSbiological_process
GO:0006816Calcium ion transportIDA IMPbiological_process
GO:0006942Regulation of striated muscle contractionIMPbiological_process
GO:0007596Blood coagulationTASbiological_process
GO:0008152Metabolic processIDAbiological_process
GO:0008637Apoptotic mitochondrial changesIMPbiological_process
GO:0016020MembraneISScellular_component
GO:0016021Integral component of membraneIEA NAScellular_component
GO:0016529Sarcoplasmic reticulumISS NAScellular_component
GO:0019829Cation-transporting ATPase activityIEAmolecular_function
GO:0031095Platelet dense tubular network membraneTAScellular_component
GO:0031448Positive regulation of fast-twitch skeletal muscle fiber contractionIDAbiological_process
GO:0031673H zoneIDAcellular_component
GO:0031674I bandIDAcellular_component
GO:0032470Positive regulation of endoplasmic reticulum calcium ion concentrationIMPbiological_process
GO:0032471Negative regulation of endoplasmic reticulum calcium ion concentrationIMPbiological_process
GO:0033017Sarcoplasmic reticulum membraneIC TAScellular_component
GO:0034220Ion transmembrane transportIDA TASbiological_process
GO:0034704Calcium channel complexICcellular_component
GO:0034976Response to endoplasmic reticulum stressIMPbiological_process
GO:0042803Protein homodimerization activityIPImolecular_function
GO:0045988Negative regulation of striated muscle contractionIMPbiological_process
GO:0046872Metal ion bindingIEAmolecular_function
GO:0048471Perinuclear region of cytoplasmISScellular_component
GO:0051561Positive regulation of mitochondrial calcium ion concentrationIMPbiological_process
GO:0051659Maintenance of mitochondrion locationIMPbiological_process
GO:0055085Transmembrane transportIDA TASbiological_process
GO:0070059Intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stressIMPbiological_process
GO:0070509Calcium ion importIMPbiological_process
GO:0070588Calcium ion transmembrane transportIDAbiological_process
GO:0090076Relaxation of skeletal muscleIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.78482177730.80519426310.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0695213309
GSE13712_SHEARDown-0.2406107760
GSE13712_STATICDown-0.0449632544
GSE19018Up0.0415231879
GSE19899_A1Down-0.0805258205
GSE19899_A2Down-0.0974140239
PubMed_21979375_A1Up0.0608271580
PubMed_21979375_A2Up0.1771381099
GSE35957Up0.0099915032
GSE36640Up0.1501289953
GSE54402Up0.0432926433
GSE9593Down-0.0582472681
GSE43922Up0.0155691512
GSE24585Up0.1966213947
GSE37065Down-0.0056761403
GSE28863_A1Down-0.0493382691
GSE28863_A2Up0.0797377869
GSE28863_A3Up0.1491050686
GSE28863_A4Up0.0898586585
GSE48662Up0.0339815477

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

Adenosine-5'-[Beta, Gamma-Methylene]TriphosphateDB03909 EXPT00416
Tetrafluoroaluminate IonDB04444 EXPT00497
2,5-DI-(TERT-BUTYL)-1,4,BENZOHYDROQUINONEDB04638 -
(6AR,11AS,11BR)-10-ACETYL-9-HYDROXY-7,7-DIMETHYL-2,6,6A,7,11A,11B-HEXAHYDRO-11H-PYRROLO[1',2':2,3]ISOINDOLO[4,5,6-CD]INDOL-11-ONEDB07604 -

  • MicroRNAs

    • mirTarBase
No target information from mirTarBase
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.