HCSGD entry for ATP2A1

1. General information

Official gene symbol	ATP2A1
Entrez ID	487
Gene full name	ATPase, Ca++ transporting, cardiac muscle, fast twitch 1
Other gene symbols	ATP2A SERCA1
Links to Entrez Gene	Links to Entrez Gene

2. Neighbors in the network

This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID	GO term	Evidence	Category
GO:0000166	Nucleotide binding	IEA	molecular_function
GO:0005388	Calcium-transporting ATPase activity	IDA IEA	molecular_function
GO:0005509	Calcium ion binding	IMP ISS	molecular_function
GO:0005515	Protein binding	IPI	molecular_function
GO:0005524	ATP binding	IEA ISS	molecular_function
GO:0005789	Endoplasmic reticulum membrane	IDA TAS	cellular_component
GO:0005793	Endoplasmic reticulum-Golgi intermediate compartment	ISS	cellular_component
GO:0006200	ATP catabolic process	IDA ISS	biological_process
GO:0006816	Calcium ion transport	IDA IMP	biological_process
GO:0006942	Regulation of striated muscle contraction	IMP	biological_process
GO:0007596	Blood coagulation	TAS	biological_process
GO:0008152	Metabolic process	IDA	biological_process
GO:0008637	Apoptotic mitochondrial changes	IMP	biological_process
GO:0016020	Membrane	ISS	cellular_component
GO:0016021	Integral component of membrane	IEA NAS	cellular_component
GO:0016529	Sarcoplasmic reticulum	ISS NAS	cellular_component
GO:0019829	Cation-transporting ATPase activity	IEA	molecular_function
GO:0031095	Platelet dense tubular network membrane	TAS	cellular_component
GO:0031448	Positive regulation of fast-twitch skeletal muscle fiber contraction	IDA	biological_process
GO:0031673	H zone	IDA	cellular_component
GO:0031674	I band	IDA	cellular_component
GO:0032470	Positive regulation of endoplasmic reticulum calcium ion concentration	IMP	biological_process
GO:0032471	Negative regulation of endoplasmic reticulum calcium ion concentration	IMP	biological_process
GO:0033017	Sarcoplasmic reticulum membrane	IC TAS	cellular_component
GO:0034220	Ion transmembrane transport	IDA TAS	biological_process
GO:0034704	Calcium channel complex	IC	cellular_component
GO:0034976	Response to endoplasmic reticulum stress	IMP	biological_process
GO:0042803	Protein homodimerization activity	IPI	molecular_function
GO:0045988	Negative regulation of striated muscle contraction	IMP	biological_process
GO:0046872	Metal ion binding	IEA	molecular_function
GO:0048471	Perinuclear region of cytoplasm	ISS	cellular_component
GO:0051561	Positive regulation of mitochondrial calcium ion concentration	IMP	biological_process
GO:0051659	Maintenance of mitochondrion location	IMP	biological_process
GO:0055085	Transmembrane transport	IDA TAS	biological_process
GO:0070059	Intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	IMP	biological_process
GO:0070509	Calcium ion import	IMP	biological_process
GO:0070588	Calcium ion transmembrane transport	IDA	biological_process
GO:0090076	Relaxation of skeletal muscle	IDA	biological_process

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4. Expression levels in datasets

Meta-analysis result

p-value up	p-value down	FDR up	FDR down
0.7848217773	0.8051942631	0.9999902473	1.0000000000

Individual experiment result
( "-" represent NA in the specific microarray platform )

Data source	Up or down	Log fold change
GSE11954	Down	-0.0695213309
GSE13712_SHEAR	Down	-0.2406107760
GSE13712_STATIC	Down	-0.0449632544
GSE19018	Up	0.0415231879
GSE19899_A1	Down	-0.0805258205
GSE19899_A2	Down	-0.0974140239
PubMed_21979375_A1	Up	0.0608271580
PubMed_21979375_A2	Up	0.1771381099
GSE35957	Up	0.0099915032
GSE36640	Up	0.1501289953
GSE54402	Up	0.0432926433
GSE9593	Down	-0.0582472681
GSE43922	Up	0.0155691512
GSE24585	Up	0.1966213947
GSE37065	Down	-0.0056761403
GSE28863_A1	Down	-0.0493382691
GSE28863_A2	Up	0.0797377869
GSE28863_A3	Up	0.1491050686
GSE28863_A4	Up	0.0898586585
GSE48662	Up	0.0339815477

5. Regulation relationships with compounds/drugs/microRNAs

Compounds

Not regulated by compounds

Drugs

Name	Drug	Accession number
Adenosine-5'-[Beta, Gamma-Methylene]Triphosphate	DB03909	EXPT00416
Tetrafluoroaluminate Ion	DB04444	EXPT00497
2,5-DI-(TERT-BUTYL)-1,4,BENZOHYDROQUINONE	DB04638	-
(6AR,11AS,11BR)-10-ACETYL-9-HYDROXY-7,7-DIMETHYL-2,6,6A,7,11A,11B-HEXAHYDRO-11H-PYRROLO[1',2':2,3]ISOINDOLO[4,5,6-CD]INDOL-11-ONE	DB07604	-

MicroRNAs

mirTarBase

No target information from mirTarBase

mirRecord

No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.

Navigator

1.General information
2.Neighbors in the network
3.Gene Ontology Annotation
4.Expression levels
5.Regulation
6.Text-mining results

HCSGD entry for ATP2A1

1. General information

2. Neighbors in the network

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

4. Expression levels in datasets

Meta-analysis result

Individual experiment result ( "-" represent NA in the specific microarray platform )

( "-" represent NA in the specific microarray platform )

5. Regulation relationships with compounds/drugs/microRNAs

Compounds

Drugs

Name

Drug

Accession number

MicroRNAs

mirTarBase

mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.

Navigator

Individual experiment result
( "-" represent NA in the specific microarray platform )