HCSGD entry for NOTCH4

1. General information

Official gene symbolNOTCH4
Entrez ID4855
Gene full namenotch 4
Other gene symbolsINT3 NOTCH3
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000139Golgi membraneTAScellular_component
GO:0001569Patterning of blood vesselsISSbiological_process
GO:0001709Cell fate determinationTASbiological_process
GO:0001763Morphogenesis of a branching structureISSbiological_process
GO:0001886Endothelial cell morphogenesisIEAbiological_process
GO:0004872Receptor activityTASmolecular_function
GO:0005509Calcium ion bindingTASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005576Extracellular regionTAScellular_component
GO:0005634NucleusTAScellular_component
GO:0005654NucleoplasmTAScellular_component
GO:0005789Endoplasmic reticulum membraneTAScellular_component
GO:0005829CytosolTAScellular_component
GO:0005886Plasma membraneTAScellular_component
GO:0005887Integral component of plasma membraneTAScellular_component
GO:0006367Transcription initiation from RNA polymerase II promoterTASbiological_process
GO:0007219Notch signaling pathwayTASbiological_process
GO:0007220Notch receptor processingTASbiological_process
GO:0007221Positive regulation of transcription of Notch receptor targetTASbiological_process
GO:0009790Embryo developmentISSbiological_process
GO:0009986Cell surfaceIDAcellular_component
GO:0010467Gene expressionTASbiological_process
GO:0030097HemopoiesisTASbiological_process
GO:0030154Cell differentiationNASbiological_process
GO:0030879Mammary gland developmentIDAbiological_process
GO:0045596Negative regulation of cell differentiationNASbiological_process
GO:0045602Negative regulation of endothelial cell differentiationISSbiological_process
GO:0045893Positive regulation of transcription, DNA-templatedTASbiological_process
GO:0046982Protein heterodimerization activityTASmolecular_function
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.20277456400.93198395200.86929377951.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0306444038
GSE13712_SHEARUp0.6177385456
GSE13712_STATICDown-0.3256809079
GSE19018Up0.3093228879
GSE19899_A1Down-0.0494137983
GSE19899_A2Up0.0979560437
PubMed_21979375_A1Down-0.1128419304
PubMed_21979375_A2Up0.0503889481
GSE35957Up0.1316975951
GSE36640Down-0.1286631182
GSE54402Up0.2879949221
GSE9593Up0.1870329249
GSE43922Up0.0550519644
GSE24585Up0.1314884343
GSE37065Down-0.0474701386
GSE28863_A1Down-0.0593413480
GSE28863_A2Up0.1094422580
GSE28863_A3Up0.3939848893
GSE28863_A4Up0.1154621257
GSE48662Down-0.1555126917

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-34c-5pMIMAT0000686MIRT006192EMSA//Luciferase reporter assay//Western blotFunctional MTI22074923
hsa-miR-181c-5pMIMAT0000258MIRT003211Luciferase reporter assay//qRT-PCR//Western blotFunctional MTI20080834
hsa-miR-18a-3pMIMAT0002891MIRT040767CLASHFunctional MTI (Weak)23622248
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    • mirRecord

MicroRNA name

mirBase ID

Target site number

MiRNA mature ID

Test method inter

MiRNA regulation site

Reporter target site

Pubmed ID

hsa-miR-181c-5pMIMAT00002581hsa-miR-181c{Western blot}{overexpression by miRNA precursor transfection}20080834
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6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.