HCSGD entry for NOTCH4

1. General information

Official gene symbolNOTCH4
Entrez ID4855
Gene full namenotch 4
Other gene symbolsINT3 NOTCH3
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000139Golgi membraneTAScellular_component
GO:0001569Patterning of blood vesselsISSbiological_process
GO:0001709Cell fate determinationTASbiological_process
GO:0001763Morphogenesis of a branching structureISSbiological_process
GO:0001886Endothelial cell morphogenesisIEAbiological_process
GO:0004872Receptor activityTASmolecular_function
GO:0005509Calcium ion bindingTASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005576Extracellular regionTAScellular_component
GO:0005634NucleusTAScellular_component
GO:0005654NucleoplasmTAScellular_component
GO:0005789Endoplasmic reticulum membraneTAScellular_component
GO:0005829CytosolTAScellular_component
GO:0005886Plasma membraneTAScellular_component
GO:0005887Integral component of plasma membraneTAScellular_component
GO:0006367Transcription initiation from RNA polymerase II promoterTASbiological_process
GO:0007219Notch signaling pathwayTASbiological_process
GO:0007220Notch receptor processingTASbiological_process
GO:0007221Positive regulation of transcription of Notch receptor targetTASbiological_process
GO:0009790Embryo developmentISSbiological_process
GO:0009986Cell surfaceIDAcellular_component
GO:0010467Gene expressionTASbiological_process
GO:0030097HemopoiesisTASbiological_process
GO:0030154Cell differentiationNASbiological_process
GO:0030879Mammary gland developmentIDAbiological_process
GO:0045596Negative regulation of cell differentiationNASbiological_process
GO:0045602Negative regulation of endothelial cell differentiationISSbiological_process
GO:0045893Positive regulation of transcription, DNA-templatedTASbiological_process
GO:0046982Protein heterodimerization activityTASmolecular_function
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.20277456400.93198395200.86929377951.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0306444038
GSE13712_SHEARUp0.6177385456
GSE13712_STATICDown-0.3256809079
GSE19018Up0.3093228879
GSE19899_A1Down-0.0494137983
GSE19899_A2Up0.0979560437
PubMed_21979375_A1Down-0.1128419304
PubMed_21979375_A2Up0.0503889481
GSE35957Up0.1316975951
GSE36640Down-0.1286631182
GSE54402Up0.2879949221
GSE9593Up0.1870329249
GSE43922Up0.0550519644
GSE24585Up0.1314884343
GSE37065Down-0.0474701386
GSE28863_A1Down-0.0593413480
GSE28863_A2Up0.1094422580
GSE28863_A3Up0.3939848893
GSE28863_A4Up0.1154621257
GSE48662Down-0.1555126917

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-34c-5pMIMAT0000686MIRT006192EMSA//Luciferase reporter assay//Western blotFunctional MTI22074923
hsa-miR-181c-5pMIMAT0000258MIRT003211Luciferase reporter assay//qRT-PCR//Western blotFunctional MTI20080834
hsa-miR-18a-3pMIMAT0002891MIRT040767CLASHFunctional MTI (Weak)23622248
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  • mirRecord

MicroRNA name

mirBase ID

Target site number

MiRNA mature ID

Test method inter

MiRNA regulation site

Reporter target site

Pubmed ID

hsa-miR-181c-5pMIMAT00002581hsa-miR-181c{Western blot}{overexpression by miRNA precursor transfection}20080834
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6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.