HCSGD entry for NKX6-1

1. General information

Official gene symbolNKX6-1
Entrez ID4825
Gene full nameNK6 homeobox 1
Other gene symbolsNKX6.1 NKX6A
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000122Negative regulation of transcription from RNA polymerase II promoterISSbiological_process
GO:0000976Transcription regulatory region sequence-specific DNA bindingIEAmolecular_function
GO:0003323Type B pancreatic cell developmentIEAbiological_process
GO:0003682Chromatin bindingIEAmolecular_function
GO:0003700Sequence-specific DNA binding transcription factor activityIEAmolecular_function
GO:0005634NucleusIDA IEAcellular_component
GO:0005730NucleolusIDAcellular_component
GO:0006366Transcription from RNA polymerase II promoterIEAbiological_process
GO:0007224Smoothened signaling pathwayIEAbiological_process
GO:0008283Cell proliferationIEAbiological_process
GO:0009887Organ morphogenesisTASbiological_process
GO:0021912Regulation of transcription from RNA polymerase II promoter involved in spinal cord motor neuron fate specificationIEAbiological_process
GO:0021913Regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specificationIEAbiological_process
GO:0031016Pancreas developmentISSbiological_process
GO:0031018Endocrine pancreas developmentTASbiological_process
GO:0032024Positive regulation of insulin secretionIEAbiological_process
GO:0035094Response to nicotineIEAbiological_process
GO:0042493Response to drugIEAbiological_process
GO:0043565Sequence-specific DNA bindingIEAmolecular_function
GO:0045666Positive regulation of neuron differentiationIEAbiological_process
GO:0045686Negative regulation of glial cell differentiationIEAbiological_process
GO:0045687Positive regulation of glial cell differentiationIEAbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterISSbiological_process
GO:0048709Oligodendrocyte differentiationIEAbiological_process
GO:0051091Positive regulation of sequence-specific DNA binding transcription factor activityISSbiological_process
GO:0051594Detection of glucoseISSbiological_process
GO:0071345Cellular response to cytokine stimulusIEAbiological_process
GO:0071375Cellular response to peptide hormone stimulusIEAbiological_process
GO:0072560Type B pancreatic cell maturationISSbiological_process
GO:2000078Positive regulation of type B pancreatic cell developmentISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.54417430950.83306181000.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0727001234
GSE13712_SHEARDown-0.1883524333
GSE13712_STATICDown-0.0319431309
GSE19018Down-0.1080151322
GSE19899_A1Down-0.0842362508
GSE19899_A2Up0.1589643785
PubMed_21979375_A1Up0.3002340614
PubMed_21979375_A2Up0.1059326065
GSE35957Down-0.1899863695
GSE36640Down-0.0824616176
GSE54402Up0.0376184340
GSE9593Down-0.0270113906
GSE43922Up0.1425747137
GSE24585Down-0.0238882070
GSE37065Down-0.0335940126
GSE28863_A1Down-0.1287195049
GSE28863_A2Up0.0363551456
GSE28863_A3Up0.3745759056
GSE28863_A4Up0.2046776067
GSE48662Up0.0713209875

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-196a-5pMIMAT0000226MIRT048171CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.