HCSGD entry for NKX6-1

1. General information

Official gene symbolNKX6-1
Entrez ID4825
Gene full nameNK6 homeobox 1
Other gene symbolsNKX6.1 NKX6A
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000122Negative regulation of transcription from RNA polymerase II promoterISSbiological_process
GO:0000976Transcription regulatory region sequence-specific DNA bindingIEAmolecular_function
GO:0003323Type B pancreatic cell developmentIEAbiological_process
GO:0003682Chromatin bindingIEAmolecular_function
GO:0003700Sequence-specific DNA binding transcription factor activityIEAmolecular_function
GO:0005634NucleusIDA IEAcellular_component
GO:0005730NucleolusIDAcellular_component
GO:0006366Transcription from RNA polymerase II promoterIEAbiological_process
GO:0007224Smoothened signaling pathwayIEAbiological_process
GO:0008283Cell proliferationIEAbiological_process
GO:0009887Organ morphogenesisTASbiological_process
GO:0021912Regulation of transcription from RNA polymerase II promoter involved in spinal cord motor neuron fate specificationIEAbiological_process
GO:0021913Regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specificationIEAbiological_process
GO:0031016Pancreas developmentISSbiological_process
GO:0031018Endocrine pancreas developmentTASbiological_process
GO:0032024Positive regulation of insulin secretionIEAbiological_process
GO:0035094Response to nicotineIEAbiological_process
GO:0042493Response to drugIEAbiological_process
GO:0043565Sequence-specific DNA bindingIEAmolecular_function
GO:0045666Positive regulation of neuron differentiationIEAbiological_process
GO:0045686Negative regulation of glial cell differentiationIEAbiological_process
GO:0045687Positive regulation of glial cell differentiationIEAbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterISSbiological_process
GO:0048709Oligodendrocyte differentiationIEAbiological_process
GO:0051091Positive regulation of sequence-specific DNA binding transcription factor activityISSbiological_process
GO:0051594Detection of glucoseISSbiological_process
GO:0071345Cellular response to cytokine stimulusIEAbiological_process
GO:0071375Cellular response to peptide hormone stimulusIEAbiological_process
GO:0072560Type B pancreatic cell maturationISSbiological_process
GO:2000078Positive regulation of type B pancreatic cell developmentISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.54417430950.83306181000.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0727001234
GSE13712_SHEARDown-0.1883524333
GSE13712_STATICDown-0.0319431309
GSE19018Down-0.1080151322
GSE19899_A1Down-0.0842362508
GSE19899_A2Up0.1589643785
PubMed_21979375_A1Up0.3002340614
PubMed_21979375_A2Up0.1059326065
GSE35957Down-0.1899863695
GSE36640Down-0.0824616176
GSE54402Up0.0376184340
GSE9593Down-0.0270113906
GSE43922Up0.1425747137
GSE24585Down-0.0238882070
GSE37065Down-0.0335940126
GSE28863_A1Down-0.1287195049
GSE28863_A2Up0.0363551456
GSE28863_A3Up0.3745759056
GSE28863_A4Up0.2046776067
GSE48662Up0.0713209875

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-196a-5pMIMAT0000226MIRT048171CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.