HCSGD entry for NFE2L2
1. General information
| Official gene symbol | NFE2L2 |
|---|---|
| Entrez ID | 4780 |
| Gene full name | nuclear factor (erythroid-derived 2)-like 2 |
| Other gene symbols | NRF2 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000785 | Chromatin | IEA | cellular_component |
| GO:0001102 | RNA polymerase II activating transcription factor binding | IPI | molecular_function |
| GO:0003677 | DNA binding | IDA IEA | molecular_function |
| GO:0003700 | Sequence-specific DNA binding transcription factor activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA IEA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005813 | Centrosome | IDA | cellular_component |
| GO:0005829 | Cytosol | IDA IEA | cellular_component |
| GO:0005886 | Plasma membrane | IDA | cellular_component |
| GO:0006366 | Transcription from RNA polymerase II promoter | TAS | biological_process |
| GO:0010499 | Proteasomal ubiquitin-independent protein catabolic process | IDA | biological_process |
| GO:0016567 | Protein ubiquitination | IDA | biological_process |
| GO:0019904 | Protein domain specific binding | IPI | molecular_function |
| GO:0030194 | Positive regulation of blood coagulation | IEA | biological_process |
| GO:0030968 | Endoplasmic reticulum unfolded protein response | IEA | biological_process |
| GO:0034599 | Cellular response to oxidative stress | IEA | biological_process |
| GO:0036003 | Positive regulation of transcription from RNA polymerase II promoter in response to stress | IMP | biological_process |
| GO:0043161 | Proteasome-mediated ubiquitin-dependent protein catabolic process | IDA | biological_process |
| GO:0043565 | Sequence-specific DNA binding | IEA | molecular_function |
| GO:0045944 | Positive regulation of transcription from RNA polymerase II promoter | IEA IMP | biological_process |
| GO:0045995 | Regulation of embryonic development | IEA | biological_process |
| GO:0060548 | Negative regulation of cell death | IEA | biological_process |
| GO:0070301 | Cellular response to hydrogen peroxide | IMP | biological_process |
| GO:0071356 | Cellular response to tumor necrosis factor | IMP | biological_process |
| GO:0071499 | Cellular response to laminar fluid shear stress | IMP | biological_process |
| GO:1902176 | Negative regulation of intrinsic apoptotic signaling pathway in response to oxidative stress | IMP | biological_process |
| GO:2000121 | Regulation of removal of superoxide radicals | IEA | biological_process |
| GO:2000352 | Negative regulation of endothelial cell apoptotic process | IMP | biological_process |
| GO:2000379 | Positive regulation of reactive oxygen species metabolic process | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.3756272596 | 0.4959626002 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0577057901 |
| GSE13712_SHEAR | Up | 0.4574041367 |
| GSE13712_STATIC | Up | 0.0191068733 |
| GSE19018 | Up | 0.1160657262 |
| GSE19899_A1 | Up | 0.0716481708 |
| GSE19899_A2 | Down | -0.1748599788 |
| PubMed_21979375_A1 | Up | 0.1201724709 |
| PubMed_21979375_A2 | Down | -0.2181674304 |
| GSE35957 | Up | 0.0912760781 |
| GSE36640 | Up | 0.0507979608 |
| GSE54402 | Down | -0.0809641654 |
| GSE9593 | Up | 0.2221971451 |
| GSE43922 | Down | -0.0321325753 |
| GSE24585 | Up | 0.3842112595 |
| GSE37065 | Up | 0.1592295552 |
| GSE28863_A1 | Up | 0.2954936258 |
| GSE28863_A2 | Up | 0.2505719840 |
| GSE28863_A3 | Down | -0.4639706440 |
| GSE28863_A4 | Down | -0.5068439301 |
| GSE48662 | Down | -0.0021957761 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-144-3p | MIMAT0000436 | MIRT007310 | Luciferase reporter assay | Functional MTI | 23236440 |
| hsa-miR-153-3p | MIMAT0000439 | MIRT007311 | Luciferase reporter assay | Functional MTI | 23236440 |
| hsa-miR-142-5p | MIMAT0000433 | MIRT007312 | Luciferase reporter assay | Functional MTI | 23236440 |
| hsa-miR-27a-3p | MIMAT0000084 | MIRT007313 | Luciferase reporter assay | Functional MTI | 23236440 |
| hsa-miR-26b-5p | MIMAT0000083 | MIRT028764 | Microarray | Functional MTI (Weak) | 19088304 |
| hsa-miR-106b-3p | MIMAT0004672 | MIRT038563 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 26391655 | This effect was attributed to nuclear translocation of the transcription factor NFE2L2 resulting in upregulation of several antioxidative enzymes |
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