HCSGD entry for NFE2L2

1. General information

Official gene symbolNFE2L2
Entrez ID4780
Gene full namenuclear factor (erythroid-derived 2)-like 2
Other gene symbolsNRF2
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000785ChromatinIEAcellular_component
GO:0001102RNA polymerase II activating transcription factor bindingIPImolecular_function
GO:0003677DNA bindingIDA IEAmolecular_function
GO:0003700Sequence-specific DNA binding transcription factor activityIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDA IEAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005813CentrosomeIDAcellular_component
GO:0005829CytosolIDA IEAcellular_component
GO:0005886Plasma membraneIDAcellular_component
GO:0006366Transcription from RNA polymerase II promoterTASbiological_process
GO:0010499Proteasomal ubiquitin-independent protein catabolic processIDAbiological_process
GO:0016567Protein ubiquitinationIDAbiological_process
GO:0019904Protein domain specific bindingIPImolecular_function
GO:0030194Positive regulation of blood coagulationIEAbiological_process
GO:0030968Endoplasmic reticulum unfolded protein responseIEAbiological_process
GO:0034599Cellular response to oxidative stressIEAbiological_process
GO:0036003Positive regulation of transcription from RNA polymerase II promoter in response to stressIMPbiological_process
GO:0043161Proteasome-mediated ubiquitin-dependent protein catabolic processIDAbiological_process
GO:0043565Sequence-specific DNA bindingIEAmolecular_function
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIEA IMPbiological_process
GO:0045995Regulation of embryonic developmentIEAbiological_process
GO:0060548Negative regulation of cell deathIEAbiological_process
GO:0070301Cellular response to hydrogen peroxideIMPbiological_process
GO:0071356Cellular response to tumor necrosis factorIMPbiological_process
GO:0071499Cellular response to laminar fluid shear stressIMPbiological_process
GO:1902176Negative regulation of intrinsic apoptotic signaling pathway in response to oxidative stressIMPbiological_process
GO:2000121Regulation of removal of superoxide radicalsIEAbiological_process
GO:2000352Negative regulation of endothelial cell apoptotic processIMPbiological_process
GO:2000379Positive regulation of reactive oxygen species metabolic processIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.37562725960.49596260020.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0577057901
GSE13712_SHEARUp0.4574041367
GSE13712_STATICUp0.0191068733
GSE19018Up0.1160657262
GSE19899_A1Up0.0716481708
GSE19899_A2Down-0.1748599788
PubMed_21979375_A1Up0.1201724709
PubMed_21979375_A2Down-0.2181674304
GSE35957Up0.0912760781
GSE36640Up0.0507979608
GSE54402Down-0.0809641654
GSE9593Up0.2221971451
GSE43922Down-0.0321325753
GSE24585Up0.3842112595
GSE37065Up0.1592295552
GSE28863_A1Up0.2954936258
GSE28863_A2Up0.2505719840
GSE28863_A3Down-0.4639706440
GSE28863_A4Down-0.5068439301
GSE48662Down-0.0021957761

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-144-3pMIMAT0000436MIRT007310Luciferase reporter assayFunctional MTI23236440
hsa-miR-153-3pMIMAT0000439MIRT007311Luciferase reporter assayFunctional MTI23236440
hsa-miR-142-5pMIMAT0000433MIRT007312Luciferase reporter assayFunctional MTI23236440
hsa-miR-27a-3pMIMAT0000084MIRT007313Luciferase reporter assayFunctional MTI23236440
hsa-miR-26b-5pMIMAT0000083MIRT028764MicroarrayFunctional MTI (Weak)19088304
hsa-miR-106b-3pMIMAT0004672MIRT038563CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

26391655This effect was attributed to nuclear translocation of the transcription factor NFE2L2 resulting in upregulation of several antioxidative enzymes
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