HCSGD entry for ATP1A1

1. General information

Official gene symbolATP1A1
Entrez ID476
Gene full nameATPase, Na+/K+ transporting, alpha 1 polypeptide
Other gene symbols
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0002026Regulation of the force of heart contractionIEAbiological_process
GO:0002028Regulation of sodium ion transportIEA ISSbiological_process
GO:0005391Sodium:potassium-exchanging ATPase activityIEA ISSmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005768EndosomeIEAcellular_component
GO:0005783Endoplasmic reticulumIEA ISScellular_component
GO:0005794Golgi apparatusIEA ISScellular_component
GO:0005886Plasma membraneIDA TAScellular_component
GO:0005890Sodium:potassium-exchanging ATPase complexIEAcellular_component
GO:0005901CaveolaIEAcellular_component
GO:0006200ATP catabolic processISS TASbiological_process
GO:0006754ATP biosynthetic processIEAbiological_process
GO:0008217Regulation of blood pressureIEAbiological_process
GO:0010107Potassium ion importIEAbiological_process
GO:0016020MembraneTAScellular_component
GO:0016021Integral component of membraneIEA ISScellular_component
GO:0016323Basolateral plasma membraneIEAcellular_component
GO:0019901Protein kinase bindingIEAmolecular_function
GO:0019904Protein domain specific bindingIEAmolecular_function
GO:0030315T-tubuleIEAcellular_component
GO:0030506Ankyrin bindingIEAmolecular_function
GO:0030955Potassium ion bindingIEAmolecular_function
GO:0031402Sodium ion bindingIEAmolecular_function
GO:0031947Negative regulation of glucocorticoid biosynthetic processIEAbiological_process
GO:0034220Ion transmembrane transportTASbiological_process
GO:0035725Sodium ion transmembrane transportISS TASbiological_process
GO:0042470MelanosomeIEAcellular_component
GO:0042493Response to drugIEAbiological_process
GO:0043531ADP bindingIEAmolecular_function
GO:0043548Phosphatidylinositol 3-kinase bindingIEAmolecular_function
GO:0045822Negative regulation of heart contractionIEAbiological_process
GO:0045823Positive regulation of heart contractionIEAbiological_process
GO:0045989Positive regulation of striated muscle contractionIEAbiological_process
GO:0051087Chaperone bindingIEA ISSmolecular_function
GO:0055085Transmembrane transportTASbiological_process
GO:0060081Membrane hyperpolarizationIEAbiological_process
GO:0071260Cellular response to mechanical stimulusIEAbiological_process
GO:0086004Regulation of cardiac muscle cell contractionIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.42701311880.67825225110.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.5207918080
GSE13712_SHEARDown-0.0890829127
GSE13712_STATICDown-0.0030438593
GSE19018Down-0.0271650275
GSE19899_A1Down-0.0631058877
GSE19899_A2Up0.0873598803
PubMed_21979375_A1Down-0.1525235250
PubMed_21979375_A2Up0.3214563234
GSE35957Down-0.0080016126
GSE36640Down-0.2386253642
GSE54402Down-0.0320019227
GSE9593Up0.1486356505
GSE43922Up0.2551374244
GSE24585Down-0.0182375973
GSE37065Up0.0846994674
GSE28863_A1Up0.0171653861
GSE28863_A2Up0.3551536865
GSE28863_A3Down-0.5474315493
GSE28863_A4Down-0.2356409402
GSE48662Up0.1307888128

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

AcetyldigitoxinDB00511 APRD01334
HydroflumethiazideDB00774 APRD01020
Etacrynic acidDB00903 APRD00251
TrichlormethiazideDB01021 APRD00031
OuabainDB01092 APRD00135
DiazoxideDB01119 APRD00914
BretyliumDB01158 APRD00830
CiclopiroxDB01188 APRD00871
BepridilDB01244 APRD00727
PotassiumDB01345 -
AluminiumDB01370 -
MagnesiumDB01378 -
DigitoxinDB01396 -
AlmitrineDB01430 -

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-193b-3pMIMAT0002819MIRT016292ProteomicsFunctional MTI (Weak)21512034
hsa-miR-340-5pMIMAT0004692MIRT019537SequencingFunctional MTI (Weak)20371350
hsa-miR-26b-5pMIMAT0000083MIRT028862MicroarrayFunctional MTI (Weak)19088304
hsa-miR-93-3pMIMAT0004509MIRT038912CLASHFunctional MTI (Weak)23622248
hsa-miR-484MIMAT0002174MIRT041714CLASHFunctional MTI (Weak)23622248
hsa-miR-320aMIMAT0000510MIRT044531CLASHFunctional MTI (Weak)23622248
hsa-miR-23b-3pMIMAT0000418MIRT046260CLASHFunctional MTI (Weak)23622248
hsa-miR-30d-5pMIMAT0000245MIRT047825CLASHFunctional MTI (Weak)23622248
hsa-miR-197-3pMIMAT0000227MIRT048123CLASHFunctional MTI (Weak)23622248
hsa-miR-196a-5pMIMAT0000226MIRT048222CLASHFunctional MTI (Weak)23622248
hsa-miR-99a-5pMIMAT0000097MIRT048687CLASHFunctional MTI (Weak)23622248
hsa-miR-92a-3pMIMAT0000092MIRT049192CLASHFunctional MTI (Weak)23622248
hsa-miR-26a-5pMIMAT0000082MIRT050108CLASHFunctional MTI (Weak)23622248
hsa-miR-18a-5pMIMAT0000072MIRT050658CLASHFunctional MTI (Weak)23622248
hsa-let-7b-5pMIMAT0000063MIRT052345CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.