HCSGD entry for ATP1A1

1. General information

Official gene symbolATP1A1
Entrez ID476
Gene full nameATPase, Na+/K+ transporting, alpha 1 polypeptide
Other gene symbols
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0002026Regulation of the force of heart contractionIEAbiological_process
GO:0002028Regulation of sodium ion transportIEA ISSbiological_process
GO:0005391Sodium:potassium-exchanging ATPase activityIEA ISSmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005768EndosomeIEAcellular_component
GO:0005783Endoplasmic reticulumIEA ISScellular_component
GO:0005794Golgi apparatusIEA ISScellular_component
GO:0005886Plasma membraneIDA TAScellular_component
GO:0005890Sodium:potassium-exchanging ATPase complexIEAcellular_component
GO:0005901CaveolaIEAcellular_component
GO:0006200ATP catabolic processISS TASbiological_process
GO:0006754ATP biosynthetic processIEAbiological_process
GO:0008217Regulation of blood pressureIEAbiological_process
GO:0010107Potassium ion importIEAbiological_process
GO:0016020MembraneTAScellular_component
GO:0016021Integral component of membraneIEA ISScellular_component
GO:0016323Basolateral plasma membraneIEAcellular_component
GO:0019901Protein kinase bindingIEAmolecular_function
GO:0019904Protein domain specific bindingIEAmolecular_function
GO:0030315T-tubuleIEAcellular_component
GO:0030506Ankyrin bindingIEAmolecular_function
GO:0030955Potassium ion bindingIEAmolecular_function
GO:0031402Sodium ion bindingIEAmolecular_function
GO:0031947Negative regulation of glucocorticoid biosynthetic processIEAbiological_process
GO:0034220Ion transmembrane transportTASbiological_process
GO:0035725Sodium ion transmembrane transportISS TASbiological_process
GO:0042470MelanosomeIEAcellular_component
GO:0042493Response to drugIEAbiological_process
GO:0043531ADP bindingIEAmolecular_function
GO:0043548Phosphatidylinositol 3-kinase bindingIEAmolecular_function
GO:0045822Negative regulation of heart contractionIEAbiological_process
GO:0045823Positive regulation of heart contractionIEAbiological_process
GO:0045989Positive regulation of striated muscle contractionIEAbiological_process
GO:0051087Chaperone bindingIEA ISSmolecular_function
GO:0055085Transmembrane transportTASbiological_process
GO:0060081Membrane hyperpolarizationIEAbiological_process
GO:0071260Cellular response to mechanical stimulusIEAbiological_process
GO:0086004Regulation of cardiac muscle cell contractionIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.42701311880.67825225110.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.5207918080
GSE13712_SHEARDown-0.0890829127
GSE13712_STATICDown-0.0030438593
GSE19018Down-0.0271650275
GSE19899_A1Down-0.0631058877
GSE19899_A2Up0.0873598803
PubMed_21979375_A1Down-0.1525235250
PubMed_21979375_A2Up0.3214563234
GSE35957Down-0.0080016126
GSE36640Down-0.2386253642
GSE54402Down-0.0320019227
GSE9593Up0.1486356505
GSE43922Up0.2551374244
GSE24585Down-0.0182375973
GSE37065Up0.0846994674
GSE28863_A1Up0.0171653861
GSE28863_A2Up0.3551536865
GSE28863_A3Down-0.5474315493
GSE28863_A4Down-0.2356409402
GSE48662Up0.1307888128

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

AcetyldigitoxinDB00511 APRD01334
HydroflumethiazideDB00774 APRD01020
Etacrynic acidDB00903 APRD00251
TrichlormethiazideDB01021 APRD00031
OuabainDB01092 APRD00135
DiazoxideDB01119 APRD00914
BretyliumDB01158 APRD00830
CiclopiroxDB01188 APRD00871
BepridilDB01244 APRD00727
PotassiumDB01345 -
AluminiumDB01370 -
MagnesiumDB01378 -
DigitoxinDB01396 -
AlmitrineDB01430 -

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-193b-3pMIMAT0002819MIRT016292ProteomicsFunctional MTI (Weak)21512034
hsa-miR-340-5pMIMAT0004692MIRT019537SequencingFunctional MTI (Weak)20371350
hsa-miR-26b-5pMIMAT0000083MIRT028862MicroarrayFunctional MTI (Weak)19088304
hsa-miR-93-3pMIMAT0004509MIRT038912CLASHFunctional MTI (Weak)23622248
hsa-miR-484MIMAT0002174MIRT041714CLASHFunctional MTI (Weak)23622248
hsa-miR-320aMIMAT0000510MIRT044531CLASHFunctional MTI (Weak)23622248
hsa-miR-23b-3pMIMAT0000418MIRT046260CLASHFunctional MTI (Weak)23622248
hsa-miR-30d-5pMIMAT0000245MIRT047825CLASHFunctional MTI (Weak)23622248
hsa-miR-197-3pMIMAT0000227MIRT048123CLASHFunctional MTI (Weak)23622248
hsa-miR-196a-5pMIMAT0000226MIRT048222CLASHFunctional MTI (Weak)23622248
hsa-miR-99a-5pMIMAT0000097MIRT048687CLASHFunctional MTI (Weak)23622248
hsa-miR-92a-3pMIMAT0000092MIRT049192CLASHFunctional MTI (Weak)23622248
hsa-miR-26a-5pMIMAT0000082MIRT050108CLASHFunctional MTI (Weak)23622248
hsa-miR-18a-5pMIMAT0000072MIRT050658CLASHFunctional MTI (Weak)23622248
hsa-let-7b-5pMIMAT0000063MIRT052345CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.