HCSGD entry for NEK2

1. General information

Official gene symbolNEK2
Entrez ID4751
Gene full nameNIMA-related kinase 2
Other gene symbolsHsPK21 NEK2A NLK1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000070Mitotic sister chromatid segregationIEAbiological_process
GO:0000086G2/M transition of mitotic cell cycleTASbiological_process
GO:0000278Mitotic cell cycleTASbiological_process
GO:0000776KinetochoreIDAcellular_component
GO:0000777Condensed chromosome kinetochoreIEAcellular_component
GO:0000794Condensed nuclear chromosomeIEAcellular_component
GO:0000922Spindle poleIEAcellular_component
GO:0001824Blastocyst developmentIEAbiological_process
GO:0004672Protein kinase activityIDAmolecular_function
GO:0004674Protein serine/threonine kinase activityIEA TASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005730NucleolusIEAcellular_component
GO:0005813CentrosomeIDAcellular_component
GO:0005829CytosolTAScellular_component
GO:0005874MicrotubuleIEAcellular_component
GO:0006468Protein phosphorylationIDAbiological_process
GO:0007059Chromosome segregationIDAbiological_process
GO:0007067MitosisTASbiological_process
GO:0007088Regulation of mitosisTASbiological_process
GO:0007126MeiosisIEAbiological_process
GO:0019903Protein phosphatase bindingIPImolecular_function
GO:0030496MidbodyIEAcellular_component
GO:0043234Protein complexIMPcellular_component
GO:0043392Negative regulation of DNA bindingIEAbiological_process
GO:0046602Regulation of mitotic centrosome separationTASbiological_process
GO:0046777Protein autophosphorylationIDA IMPbiological_process
GO:0046872Metal ion bindingIEAmolecular_function
GO:0051225Spindle assemblyTASbiological_process
GO:0051299Centrosome separationIDAbiological_process
GO:0051988Regulation of attachment of spindle microtubules to kinetochoreIMPbiological_process
GO:0090307Spindle assembly involved in mitosisIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.93276191250.00001003000.99999024730.0069833333

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-1.6585422339
GSE13712_SHEARDown-0.7295140402
GSE13712_STATICDown-0.8832345416
GSE19018Up0.2317883514
GSE19899_A1Down-1.2948256452
GSE19899_A2Down-5.0169251736
PubMed_21979375_A1Down-4.5064921894
PubMed_21979375_A2Down-5.8747315079
GSE35957Down-3.6580820056
GSE36640Down-6.2316020748
GSE54402Down-1.5770629066
GSE9593Down-1.4376794761
GSE43922Down-2.4783614604
GSE24585Up0.2522007335
GSE37065Down-0.5906606036
GSE28863_A1Down-0.1905167267
GSE28863_A2Up0.5725967771
GSE28863_A3Up0.0347311650
GSE28863_A4Up0.2459925470
GSE48662Down-1.0083063883

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

5-[(Z)-(5-CHLORO-2-OXO-1,2-DIHYDRO-3H-INDOL-3-YLIDENE)METHYL]-N-(DIETHYLAMINO)ETHYL]-2,4-DIMETHYL-1H-PYRROLE-3-CARBOXAMIDEDB07180 -

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-128-3pMIMAT0000424MIRT022077MicroarrayFunctional MTI (Weak)17612493
hsa-miR-92a-3pMIMAT0000092MIRT048925CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.