HCSGD entry for NEK2

1. General information

Official gene symbolNEK2
Entrez ID4751
Gene full nameNIMA-related kinase 2
Other gene symbolsHsPK21 NEK2A NLK1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000070Mitotic sister chromatid segregationIEAbiological_process
GO:0000086G2/M transition of mitotic cell cycleTASbiological_process
GO:0000278Mitotic cell cycleTASbiological_process
GO:0000776KinetochoreIDAcellular_component
GO:0000777Condensed chromosome kinetochoreIEAcellular_component
GO:0000794Condensed nuclear chromosomeIEAcellular_component
GO:0000922Spindle poleIEAcellular_component
GO:0001824Blastocyst developmentIEAbiological_process
GO:0004672Protein kinase activityIDAmolecular_function
GO:0004674Protein serine/threonine kinase activityIEA TASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005730NucleolusIEAcellular_component
GO:0005813CentrosomeIDAcellular_component
GO:0005829CytosolTAScellular_component
GO:0005874MicrotubuleIEAcellular_component
GO:0006468Protein phosphorylationIDAbiological_process
GO:0007059Chromosome segregationIDAbiological_process
GO:0007067MitosisTASbiological_process
GO:0007088Regulation of mitosisTASbiological_process
GO:0007126MeiosisIEAbiological_process
GO:0019903Protein phosphatase bindingIPImolecular_function
GO:0030496MidbodyIEAcellular_component
GO:0043234Protein complexIMPcellular_component
GO:0043392Negative regulation of DNA bindingIEAbiological_process
GO:0046602Regulation of mitotic centrosome separationTASbiological_process
GO:0046777Protein autophosphorylationIDA IMPbiological_process
GO:0046872Metal ion bindingIEAmolecular_function
GO:0051225Spindle assemblyTASbiological_process
GO:0051299Centrosome separationIDAbiological_process
GO:0051988Regulation of attachment of spindle microtubules to kinetochoreIMPbiological_process
GO:0090307Spindle assembly involved in mitosisIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.93276191250.00001003000.99999024730.0069833333

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-1.6585422339
GSE13712_SHEARDown-0.7295140402
GSE13712_STATICDown-0.8832345416
GSE19018Up0.2317883514
GSE19899_A1Down-1.2948256452
GSE19899_A2Down-5.0169251736
PubMed_21979375_A1Down-4.5064921894
PubMed_21979375_A2Down-5.8747315079
GSE35957Down-3.6580820056
GSE36640Down-6.2316020748
GSE54402Down-1.5770629066
GSE9593Down-1.4376794761
GSE43922Down-2.4783614604
GSE24585Up0.2522007335
GSE37065Down-0.5906606036
GSE28863_A1Down-0.1905167267
GSE28863_A2Up0.5725967771
GSE28863_A3Up0.0347311650
GSE28863_A4Up0.2459925470
GSE48662Down-1.0083063883

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

5-[(Z)-(5-CHLORO-2-OXO-1,2-DIHYDRO-3H-INDOL-3-YLIDENE)METHYL]-N-(DIETHYLAMINO)ETHYL]-2,4-DIMETHYL-1H-PYRROLE-3-CARBOXAMIDEDB07180 -

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-128-3pMIMAT0000424MIRT022077MicroarrayFunctional MTI (Weak)17612493
hsa-miR-92a-3pMIMAT0000092MIRT048925CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.